Title:Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells
VOLUME: 21
Author(s):Qiuyan Guo and Enshe Jiang*
Affiliation:College of Medicine, Xuchang University, Xuchang, Institutes of Nursing and Health, Henan Medical School, Henan University, Kaifeng
Keywords:Podophyllotoxin, epipodophyllotoxin, anticancer, multidrug resistance, mechanism of action, structure-activity relationship.
Abstract:Podophyllotoxins including epipodophyllotoxin derivatives can act on a diverse array
of drug targets in cancer cells, and thus possess potential activity against various forms of cancer
cell lines including drug-resistant forms. Moreover, several podophyllotoxin derivatives which are
represented by etoposide and teniposide have already been approved for the cancer therapy,
demonstrating podophyllotoxin moiety is a useful pharmacophore for the discovery of novel
anticancer agents. This review reports the recent advances in exploitation of podophyllotoxin
derivatives to fight against multidrug-resistant cancer cells. The mechanism of action and
structure-activity relationship (SAR) studies are also highlighted.
