Recent Advances in the Application of Podophyllotoxin Derivatives to Fight Against Multidrug-Resistant Cancer Cells

(E-pub Ahead of Print)

Author(s): Qiuyan Guo, Enshe Jiang*

Journal Name: Current Topics in Medicinal Chemistry


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Abstract:

Podophyllotoxins including epipodophyllotoxin derivatives can act on a diverse array of drug targets in cancer cells, and thus possess potential activity against various forms of cancer cell lines including drug-resistant forms. Moreover, several podophyllotoxin derivatives which are represented by etoposide and teniposide have already been approved for the cancer therapy, demonstrating podophyllotoxin moiety is a useful pharmacophore for the discovery of novel anticancer agents. This review reports the recent advances in exploitation of podophyllotoxin derivatives to fight against multidrug-resistant cancer cells. The mechanism of action and structure-activity relationship (SAR) studies are also highlighted.

Keywords: Podophyllotoxin, epipodophyllotoxin, anticancer, multidrug resistance, mechanism of action, structure-activity relationship.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1568026621666210113163327
Price: $95

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