Targeted Radionuclide Therapies (TRTs) based on Auger emitting radionuclides have
the potential to deliver extremely selective therapeutic payloads on the cellular level. However, to
fully exploit this potential, suitable radionuclides need to be applied in combination with appropriate
delivery systems. In this review, we summarize the state-of-the-art production, purification, chelation
and applications of two promising candidates for Targeted Auger Therapy, namely antimony-
119 (119Sb) and mercury-197 (197Hg). Both radionuclides have great potential to become efficient
tools for TRT. We also highlight our current progress on the production of both radionuclides
at TRIUMF and the University of Wisconsin.
Keywords: Targeted Radionuclide Therapy (TRT), auger electrons, mercury-197 (197Hg), antimony-119 (119Sb), production, radiochemical
separation, coordination, imaging, dosimetry.
Rights & PermissionsPrintExport