A Review on Synthesis, Reactions and Biological Properties of Seven Membered Heterocyclic Compounds: Azepine, Azepane, Azepinone

Manvinder       Kaur; Sonali       Garg; Dharambeer    S.    Malhi; Harvinder    S.    Sohal
Abstract

Seven membered heterocyclic Azepine and its derivatives have great pharmacological and therapeutic implications. In this review, the literature of the last fifty years has been exploited for the synthesis, reaction, and biological properties of these seven-member heterocyclic compounds. Most of the mechanisms involved the ring expansion of either five or six-membered compounds using various methods such as thermally, photo-chemically, and microwave irradiation. The systematically designed schemes involve the synthesis of different derivatives of azepine, azepinone, azepane, etc., using similar moieties by various researchers. However, there is much work yet to be done in the biological section, as it is not explored and reported in the literature; therefore, N-containing seven-membered heterocycles still have much scope for the researchers.
Keywords: Azepine, azepane, azepinone, benzazepine, dibenzazepinone, thiazipine.
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DOI https://dx.doi.org/10.2174/1385272825999210104222338	Print ISSN 1385-2728
Publisher Name Bentham Science Publisher	Online ISSN 1875-5348
Current Organic Chemistry

A Review on Synthesis, Reactions and Biological Properties of Seven Membered Heterocyclic Compounds: Azepine, Azepane, Azepinone

Abstract

Graphical Abstract

Advances of Heterocyclic Chemistry with Pesticide Activity

Calculation design of covalent/metal organic framework based catalysts

Carbohydrates conversion in biofuels and bioproducts

Catalytic C-H bond activation as a tool for functionalization of heterocycles

Current Organic Chemistry

A Review on Synthesis, Reactions and Biological Properties of Seven Membered Heterocyclic Compounds: Azepine, Azepane, Azepinone

Abstract

Graphical Abstract

Call for Papers in Thematic Issues

Advances of Heterocyclic Chemistry with Pesticide Activity

Calculation design of covalent/metal organic framework based catalysts

Carbohydrates conversion in biofuels and bioproducts

Catalytic C-H bond activation as a tool for functionalization of heterocycles

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