Title:Increased level of interleukin-8 in female genital tract after HP eradication lines
VOLUME: 21
Author(s):Viacheslav Kravtsov*, Tatiana Surovtceva, Maria Taame, Yuriy Grukhin and Natalia Kalinina
Affiliation:S.M. Kirov Military Medical Academy, Saint-Petersburg, Saint-Petersburg State public health Institution “City Clinical Hospital” №.20, Saint-Petersburg, Institute of Public Health and Clinical Nutrition, University of Eastern Finland (UEF), Kuopio, Saint-Petersburg State public health Institution “City Clinical Hospital” №.20, Saint-Petersburg, Nikiforov Russian Centre of Emergency and Radiation Medicine, EMERCOM, Saint-Petersburg
Keywords:Local immunity, female genital tract, interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), Helicobacter
Pylori associated acid-related diseases, eradication lines.
Abstract:The study investigated the levels of cytokines IL-8 and TNF-α in vaginal secretion in a group of female patients
with Helicobacter-associated acid-related diseases who were or were not treated with antibiotics against anti-Helicobacter
therapy. It turned out that the secretory cytokine (chemokine) IL-8 is dramatically increased in the vaginal mucosa in patients treated with antibiotics, specifically in post-menopause women. Thus, we conclude that helicobacter pylori eradication
treatment affects the immune status of the female genital tract.
