Increased Level of Interleukin-8 in Female Genital Tract After HP Eradication Lines

Title:Increased Level of Interleukin-8 in Female Genital Tract After HP Eradication Lines

Volume: 21 Issue: 7

Author(s): Viacheslav Kravtsov*, Tatiana Surovtceva, Maria Taame, Yuriy Grukhin and Natalia Kalinina

Affiliation:

• S.M. Kirov Military Medical Academy, Saint-Petersburg,Russian Federation

Keywords: Local immunity, female genital tract, interleukin-8 (IL-8), tumor necrosis factor-alpha (TNF-α), Helicobacterpylori associated acid-related diseases, AHT, eradication lines.

Abstract: Background: Antibiotics are known to be effective in treating bacterial infectious disease. Changes in microflora and mucosal dysbiosis may take place after antibiotic treatment. We investigated in this research the effect of anti-Helicobacter pylori treatment (AHT) on local immunity of the female genital tract.

Methods: The study identified the levels of cytokines IL-8 and TNF-α in vaginal secretion in a group of female patients with Helicobacter-associated acid-related diseases who were or were not treated with antibiotics against Helicobacter Pylori.

Results: Research outcomes turned out that the secretory cytokine (chemokine) IL-8 is dramatically increased in the vaginal mucosa in patients treated with antibiotics, specifically in post-menopause women.

Conclusion: Helicobacter pylori eradication treatment affects the immune status of the female genital tract.

Cite this article as:

Kravtsov Viacheslav *, Surovtceva Tatiana, Taame Maria, Grukhin Yuriy and Kalinina Natalia , Increased Level of Interleukin-8 in Female Genital Tract After HP Eradication Lines, Infectious Disorders - Drug Targets 2021; 21 (7) : e300821189859 . https://dx.doi.org/10.2174/1871526520666210104091545