Bee Venom PLA2 versus Snake Venom PLA2: Evaluation of Structural
and Functional Properties

Lara       Bitar; Dania      Jundia; Mohamad       Rima; Jean-Marc       Sabatier; Ziad      Fajloun
Abstract

Phospholipases A2 enzymes are found in many mammalian tissues and in animal venoms. Those present in bee venom (bvPLA2) and snake venom (svPLA2) have been studied more particularly for their biological activities of interest. Although they belong to the same family of secreted PLA2 (sPLA2), bvPLA2 and svPLA2 differ from a structural and functional point of view. In this review, we describe the morphological characteristics of these two enzymes and the structural determinants that govern their functions. After describing their cytotoxicity, we compared their biological activities, including antimicrobial, anti-tumor, anti-inflammatory, anti-neurodegenerative, and anti-nociceptive effects. In addition, we highlighted their therapeutical applications and deduced that bvPLA2 has better potential than svPLA2 in biotechnological and pharmaceutical innovations.
Keywords: phospholipase A2, bee venom, snake venom, bvPLA2, svPLA2, toxicity, therapeutical applications.
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DOI https://dx.doi.org/10.2174/2666121701999210101225032	Print ISSN 2666-1217
Publisher Name Bentham Science Publisher	Online ISSN 2666-1225
Venoms and Toxins

Bee Venom PLA2 versus Snake Venom PLA2: Evaluation of Structural and Functional Properties

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