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ISSN (Print): 1573-4137
ISSN (Online): 1875-6786

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Research Article

Biomimetic Copper Oxide Nanoparticles and its Validation Through In-silico Approach on Cardiac Enzymes

Author(s): Jacquline Rosy P, VenkatKumar Shanmugam*, Jebastin Sonia Jas and Santhoshkumar Jayakodi

Volume 18, Issue 1, 2022

Published on: 01 January, 2021

Page: [86 - 93] Pages: 8

DOI: 10.2174/1573413716666210101161139

Abstract

Background: The present study outlines the green synthesis of copper oxide (GS-CuO) nanoparticles using Magnolia champaca plant floral extract for the first time. Computational analysis showed the role of GS-CuO nanoparticles on cardiac enzymes ACE2 and SOD1 functional expression through hydrogen bond interaction with amino acid residues

Method: The synthesized GS-CuO nanoparticles were characterized by various techniques like XRay Diffraction, UV-Vis Spectrophotometer, Fourier Transform Infrared Spectroscopy, Scanning Electron Microscopy and Transmission Electron Microscopy

Results: Nanoparticles demonstrate the presence of spherical shape and size 20 nm. The particles have many active sites as compared to the bulk materials, and thus, computational analysis was conducted against angiotensin-converting enzyme and superoxide dismutase to visualize the cardioprotective effects

Conclusion: The in-silico approach established valuable information on the cardioprotective effects of green synthesized oxide nanoparticles using Magnolia champaca.

Keywords: GS-CuO nanoparticles, magnolia champaca, GCMS, TEM, in-silico approach, LigPlot

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