Abstract
A novel coronavirus termed nCoV-2019 that caused an epidemic of acute respiratory syndrome in humans was first detected in Wuhan, China, in December 2019. nCoV-2019 resulted in thousands of cases of lethal disease all around the world. Unfortunately, there is no specific treatment yet, so a better understanding of the pathobiology of the disease can be helpful. The renin-angiotensin system and its products have several important physiological actions. On the other hand, this system is involved in the pathogenesis of various diseases. In this context, this review article will briefly discuss insights for understanding the role of the angiotensin-converting enzyme 2 (ACE2) receptor as a potentially attractive target for the nCoV-2019-induced acute respiratory syndrome.
Keywords: COVID-19, renin-angiotensin system, ACE2, angiotensin, SARS-like coronavirus, acute respiratory syndrome.
Current Drug Discovery Technologies
Title:ACE2 as a Potential Target for Management of Novel Coronavirus (nCoV- 2019)
Volume: 18 Issue: 6
Author(s): Elham Foroozanfar, Mohamad Forouzanfar, Tahereh Farkhondeh, Saeed Samarghandian and Fatemeh Forouzanfar*
Affiliation:
- Department of Neuroscience, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad,,Iran
Keywords: COVID-19, renin-angiotensin system, ACE2, angiotensin, SARS-like coronavirus, acute respiratory syndrome.
Abstract: A novel coronavirus termed nCoV-2019 that caused an epidemic of acute respiratory syndrome in humans was first detected in Wuhan, China, in December 2019. nCoV-2019 resulted in thousands of cases of lethal disease all around the world. Unfortunately, there is no specific treatment yet, so a better understanding of the pathobiology of the disease can be helpful. The renin-angiotensin system and its products have several important physiological actions. On the other hand, this system is involved in the pathogenesis of various diseases. In this context, this review article will briefly discuss insights for understanding the role of the angiotensin-converting enzyme 2 (ACE2) receptor as a potentially attractive target for the nCoV-2019-induced acute respiratory syndrome.
Export Options
About this article
Cite this article as:
Foroozanfar Elham , Forouzanfar Mohamad , Farkhondeh Tahereh , Samarghandian Saeed and Forouzanfar Fatemeh *, ACE2 as a Potential Target for Management of Novel Coronavirus (nCoV- 2019), Current Drug Discovery Technologies 2021; 18 (6) : e130921189567 . https://dx.doi.org/10.2174/1570163817999201228215911
DOI https://dx.doi.org/10.2174/1570163817999201228215911 |
Print ISSN 1570-1638 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6220 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Quantitative Structure-Activity Relationship (QSAR) Analysis to Predict Drug-Drug Interactions of ABC Transporter ABCG2
Mini-Reviews in Medicinal Chemistry Pathogenesis of HIV-Associated Non-Hodgkin Lymphoma
Current HIV Research Pericyclic Reactions for Antivirals: Synthesis of 4-Bromo-N-[(1R*,4S*)-4- hydroxy-2-cyclohexen-1-yl]-2-thiazolecarboxamide
Letters in Organic Chemistry Monooxime Bispyridinium Reactivators Bearing Xylene Linker Synthesis and In Vitro Evaluation on Model of Organophosphate-Inhibited Acetylcholinesterase
Medicinal Chemistry Recent Advances in N-Heterocycles for COVID-19 Treatment - A Mini Review
Medicinal Chemistry Pharmacophoric Models and 3D QSAR Studies of the Adenosine Receptor Ligands
Current Topics in Medicinal Chemistry Progress Towards the Development of a HIV-1 gp41-Directed Vaccine
Current HIV Research Mechanistic Aspects of Medicinal Plants and Secondary Metabolites against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2)
Current Pharmaceutical Design Current Perspective of COVID-19 on Neurology: A Mechanistic Insight
Combinatorial Chemistry & High Throughput Screening Self-Organizing Maps for the Classification of Gallic Acylate Polyphenols as HSV-1 Inhibitors
Medicinal Chemistry New Perspectives on Machine Learning in Drug Discovery
Current Medicinal Chemistry Developmental Regulated Expression of Anti- and Pro-Apoptotic BCL-2 Family Genes During Human Early Embryonic Development
Current Medicinal Chemistry Inhibitor Design for SARS Coronavirus Main Protease Based on “Distorted Key Theory”
Medicinal Chemistry Development, Recent Achievements and Current Directions of Research into GABA Uptake Inhibitors
Current Medicinal Chemistry Acetogenins as Potential Anticancer Agents
Anti-Cancer Agents in Medicinal Chemistry Forecasting of Covid-19 Cases Using Machine Learning Approach
Current Respiratory Medicine Reviews Recent Patents on Development of Nucleic Acid-based Antiviral Drugs against Seasonal and Pandemic Influenza Virus Infections
Recent Patents on Anti-Infective Drug Discovery Determination of Stimulants and Diuretics in Dietary Supplements for Weight Loss and Physical Fitness by Ion-pair Chromatography and Pulsed Amperometric Detection (PAD)
Current Analytical Chemistry Anti-Chlamydophila pneumoniae Antibodies as Associated Factor for Carotid Atherosclerosis in Patients with AIDS
Current HIV Research Interfering with Host Proteases in SARS-CoV-2 Entry as a Promising Therapeutic Strategy
Current Medicinal Chemistry