Title:New Viral Infection COVID-19: Current Status, Challenges and Possible Treatments
VOLUME: 18
Author(s):Vipan Kumar, Amruta Suryan, Jyoti Singh*, Sandeep Kumar, Pradeep Kamboj and Aakash Deep
Affiliation:JCDM College of Pharmacy, Barnala Road, Sirsa, Haryana, University Institute of Pharmaceutical Sciences, Panjab University, Chandigarh, Chandigarh College of Pharmacy, Landran, Punjab, State Drug Laboratory, Chandigarh, JCDM College of Pharmacy, Barnala Road, Sirsa, Haryana, Department of Pharmaceutical Sciences, Chaudhary Bansi Lal University, Bhiwani, Haryana
Keywords:SARS-CoV-2, Symptoms, Remdesivir, Structures, Convalescent plasma therapy, Vaccines candidates.
Abstract:Since December 2019, the prevalence of novel coronavirus infection (named as COVID-19 by WHO on Feb 11,
2020) has become a growing healthcare concern worldwide. On March 11, 2020, the WHO declared COVID-19 a global
pandemic. As no specific approved treatment options are available for the COVID-19 infection, several existing antiviral
drugs in combination with others have become mainstay therapy. The targets for the treatment of the infection include viral
targets such as polymerases, spike glycoproteins, membrane proteins, and viral envelope and host targets such as host
proteases and host receptors. Antiviral agents, immunomodulatory agents, and empiric broad-spectrum antibiotics can be
used as treatment therapies for the infection. Convalescent plasma therapy has also been proposed as an effective treatment
for COVID-19. Additionally, many studies are ongoing to develop a potent and effective vaccine that completely blocks
SARS-CoV-2. Nevertheless, prevention of spreading of the virus remains the first and foremost step towards controlling and
managing the coronavirus infection.
