Abstract
Microwave irradiated facile and efficient process for one pot Ugi multicomponent reaction of a novel series of fluoroquinolone scaffolds is described here. On the basis of this approach, a new route to synthesize this privileged scaffolds was designed with higher yields, a clean procedure, time efficient and simple work-up. Our aim is to develop a biologically active fluoroquinolone scaffolds by microwave induced one pot Ugi multicomponent reaction. All the synthesized molecules were characterized by IR, 1H NMR, 13C NMR, and Mass spectra. The antimicrobial activity of the synthesized compounds was screened against two Gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), two Gram-positive bacteria (Staphylococcus aureus, Streptococcus pyogenes), and three fungi (Candida albicans, Aspergillus niger, Aspergillus clavatus) utilizing the MIC (Minimal Inhibitory Concentration) method and antitubercular activity H37Rv utilizing L. J. Slope method. Some of these novel derivatives demonstrate moderate to good in vitro antibacterial, antifungal and antitubercular activities.
Keywords: Fluoroquinolone, one pot reaction, ugi multi-component reaction, antimicrobial activity, M. tuberculosis H37Rv, microwave irradiation.
Graphical Abstract
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