Generic placeholder image

Recent Patents on Biotechnology

Editor-in-Chief

ISSN (Print): 1872-2083
ISSN (Online): 2212-4012

Mini-Review Article

Patents on Violacein: A Compound with Great Diversity of Biological Activities and Industrial Potential

Author(s): Nelson Durán*, Wagner J. Fávaro, Marcelo Brocchi, Giselle Z. Justo, Guillermo R. Castro, Marcela Durán and Gerson Nakazato*

Volume 15, Issue 2, 2021

Published on: 21 December, 2020

Page: [102 - 111] Pages: 10

DOI: 10.2174/2213476X07666201221111655

Price: $65

Abstract

Background: This review outlines the current impact of violacein-derivative materials in several technological areas through patents.

Methods: A comprehensive examination of patent databases on violacein demonstrated the relevance of this pigment, as well as the pertinent topics related to its technological development in order to obtain adaptable new pharmaceuticals, cosmetics, and new quality fiber materials, together with other applications of violacein in different areas.

Results: At present, there is no efficient and economical technique for violacein preparation at the industrial scale. Many attempts have been made, but none have overcome the challenge of being an effective and inexpensive process. However, some potential applications of violacein in fields such as biomedicine make the pigment worthy of continuous investigation. In particular, violacein patents covering biosynthesis for different applications have been reported recently.

Conclusion: Violacein has been used as a unique pigment in distinct specialty areas, such as in medical and industrial fields. This review of patents provides an update on violacein innovations that are useful for researchers working in the expanding and interesting field of biotechnology with natural pigments.

Keywords: Violacein, patents, pigments, textiles, medicine, health.

Next »
Graphical Abstract
[1]
DeMoss VRD, Gottlieb D, Shaw PD, Eds. Mechanisms of action and biosynthesis of antibiotics. New York: Springer-Verlag 1967; 2: pp. 77-81.
[2]
Durán N, Justo GZ, Ferreira CV, Melo PS, Cordi L, Martins D. Violacein: properties and biological activities. Biotechnol Appl Biochem 2007; 48(Pt 3): 127-33.
[http://dx.doi.org/10.1042/BA20070115] [PMID: 17927569]
[3]
Durán M, Faljoni-Alario A, Durán N. Chromobacterium violaceum and its important metabolites-review. Folia Microbiol (Praha) 2010; 55(6): 535-47.
[http://dx.doi.org/10.1007/s12223-010-0088-4] [PMID: 21253897]
[4]
Durán M, Ponezi AN, Alario AF, et al. Potential applications of violacein: a microbial pigment. Med Chem Res 2012; 21: 1524-32.
[http://dx.doi.org/10.1007/s00044-011-9654-9]
[5]
Durán N, Justo GZ, Durán M, et al. Advances in Chromobacterium violaceum and properties of violacein-Its main secondary metabolite: a review. Biotechnol Adv 2016; 34(5): 1030-45.
[http://dx.doi.org/10.1016/j.biotechadv.2016.06.003] [PMID: 27288924]
[6]
Liu GY, Nizet V. Color me bad: microbial pigments as virulence factors. Trends Microbiol 2009; 17(9): 406-13.
[http://dx.doi.org/10.1016/j.tim.2009.06.006] [PMID: 19726196]
[7]
Hoshino T. Violacein and related tryptophan metabolites produced by Chromobacterium violaceum: biosynthetic mechanism and pathway for construction of violacein core. Appl Microbiol Biotechnol 2011; 91(6): 1463-75.
[http://dx.doi.org/10.1007/s00253-011-3468-z] [PMID: 21779844]
[8]
Thøgersen MS, Delpin MW, Melchiorsen J, et al. Production of the bioactive compounds violacein and indolmycin is conditional in a maeA mutant of Pseudoalteromonas luteoviolacea S4054 lacking the malic enzyme. Front Microbiol 2016; 7: 1461.
[http://dx.doi.org/10.3389/fmicb.2016.01461] [PMID: 27695447]
[9]
Füller JJ, Röpke R, Krausze J, et al. Biosynthesis of violacein: structure and function of L-tryptophan oxidase VioA from Chromobacterium violaceum. J Biol Chem 2016; 291(38): 20068-84.
[http://dx.doi.org/10.1074/jbc.M116.741561] [PMID: 27466367]
[10]
Kothari V, Sharma S, Padia D. Recent research advances on Chromobacterium violaceum. Asian Pac J Trop Med 2017; 10(8): 744-52.
[http://dx.doi.org/10.1016/j.apjtm.2017.07.022] [PMID: 28942822]
[11]
Justo GZ, Durán N. Action and function of Chromobacterium violaceum in health and disease: violacein as a promising metabolite to counteract gastroenterological diseases. Best Pract Res Clin Gastroenterol 2017; 31(6): 649-56.
[http://dx.doi.org/10.1016/j.bpg.2017.10.002] [PMID: 29566908]
[12]
Cazotto LL, Martins D, Ribeiro MG, et al. Antibacterial activity of violacein against Staphylococcus aureus isolated from Bovine Mastitis. J Antibiot 2011; 64: 395-7.
[http://dx.doi.org/10.1038/ja.2011.13]
[13]
Woodhams DC, LaBumbard BC, Barnhart KL, et al. Prodigiosin, violacein, and volatile organic compounds produced by widespread cutaneous bacteria of amphibians can inhibit two Batrachochytrium fungal pathogens. Microb Ecol 2018; 75(4): 1049-62.
[http://dx.doi.org/10.1007/s00248-017-1095-7] [PMID: 29119317]
[14]
Antonisamy P, Ignacimuthu S. Immunomodulatory, analgesic and antipyretic effects of violacein isolated from Chromobacterium violaceum. Phytomedicine 2010; 17(3-4): 300-4.
[http://dx.doi.org/10.1016/j.phymed.2009.05.018] [PMID: 19576742]
[15]
Venegas FA, Köllisch G, Mark K, et al. The bacterial product violacein exerts an immunostimulatory effect via TLR8. Sci Rep 2019; 9(1): 13661.
[http://dx.doi.org/10.1038/s41598-019-50038-x] [PMID: 31541142]
[16]
Durán N, Menck CF. Chromobacterium violaceum: a review of pharmacological and industiral perspectives. Crit Rev Microbiol 2001; 27(3): 201-22.
[http://dx.doi.org/10.1080/20014091096747] [PMID: 11596879]
[17]
Choi SY, Yoon KH, Lee JI, Mitchell RJ. Violacein: properties and production of a versatile Bacterial pigment. BioMed Res Int 2015; 2015: 465056.
[http://dx.doi.org/10.1155/2015/465056] [PMID: 26339614]
[18]
Venil CK, Zakaria ZA, Ahmad WA. Bacterial pigments and their applications. Process Biochem 2013; 48: 1065-79.
[http://dx.doi.org/10.1016/j.procbio.2013.06.006]
[19]
Venil CK, Aruldass CA, Dufosse L, Zakaria ZA, Ahmad WA. Current perspective on bacterial pigments: emerging sustainable compounds with coloring and biological properties for the industry - an incisive evaluation. RSC Advances 2014; 4: 39523.
[http://dx.doi.org/10.1039/C4RA06162D]
[20]
Numan M, Bashir S, Mumtaz R, et al. Therapeutic applications of bacterial pigments: a review of current status and future opportunities. 3 Biotech 2018; 8(4): 207.
[21]
May G, Lenk W, Ott H. Trans-hydroxyviolacein, process for preparing it pure and its use for the prophylaxis and therapy of viral diseases. DE3813465, 1989.
[22]
Durán N, Haun M. Production process and purification process and antitumoral activity of 3-[1,2-dihydro-5-(5-hydroxy-1H-indol-3-yl)-2-oxo-3H-pyrrol-3-ylidene]-1,3-dihydro-2H-indol-2-one. BR970 2918-1, 1997.
[23]
Durán N, Rettori D. Stationary tray bioreactor for the bacterial metabolite production. BR9702986-6, 1997.
[24]
Mendes AS, De Carvalho EJE, Duarte MCT, Durán N, Bruns RE. Violacein and deoxyviolacein production process optimized by factorial design and analysis of response surface by Chromobacterium violaceum. BR0100199-0, 2001.
[25]
Bhaskaran K. Process for the production of violacein and its derivative deoxyviolacen containing bioactive pigment from Chromobacterium sp. MTCC5522, 2011.
[26]
Zheng KIH, Chen H, Wang JD, et al. Chromobacterioum violaceum strain and application thereof. CN103173390B, 2014.
[27]
Lyu J, Zhang S, Liu L, et al. High-violacein-yield Janthinobacterium lividum and application thereof. CN104293703 (A), 2015.
[28]
Yoon SH, Lee CM, Kwon SW, Koo BS, Baek HJ. Novel microorganism producing violacein. KR20150104663A, 2016.
[29]
May G, Ott H. Treatment of prophylaxis of polio and herpes virus infections - comprise administration of 3-(di:hydro-5-(hydroxy-1H- indolyl-2-oxo-3H-pyrrolidene)-di:hydro-2H-indole. DE 3935066, 1991.
[30]
Durán N, De Azevedo MBM, Alderete J. Process of formulation of violacein/cyclodextrin for using as antibiotic, antitumoral, antiviral and as trypanocide. BR9801307-6, 1998.
[31]
Alves OL, Gimenez I, De Azevedo MMM, Durán N, Melo PS. Pharmacological use of cyclodextrin-Au-Thiol-derived nanoparticles/hydrophobic compound as antitumor, antibacterial, antiviral and/or antiparasitic, their process of obtaining and their formulation. BR0502657-1, 2005.
[32]
De Vasconcelos ATR, Simpson AJG, Abreu HNS, et al. Gene-coding polynucleotides of the chromosome of the bacterium Chromobacterium violaceum, expression and activity of these polynucleotides and their applications. WO2004056960A3, 2004.
[33]
Sarmiento JJP, Cardozo VF, Durán N, et al. Composition containing biological silver nanoparticles and a pigment produced by Chromobacterium violaceum with antibacterial activity. BR1020160033730, 2016.
[34]
Lee CS, Lee JH, Kwon JH, Mitchell RJ, Choi SY. Antibiotic medical fabric with violacein supported particle and making process thereof. KR20160050468(A), 2016.
[35]
Mitchell RJ. Antimicrobial composition comprising Bdellovibrio bacteriovorus and violacein. KR20190110886 (A), 2019.
[36]
Kim W. Nanoparticle composition having antibacterial and pyrogenic properties and its manufacturing method. US10744560, 2020.
[37]
Durán N, De Souza AO. Process of violacein application as antimycobacterial compound. BR0101346-7, 2001.
[38]
Xing X, Sun Y, Zhang C. Violacein and/or deoxyviolacein for treating colon cancer. CN108853094 (A), 2018.
[39]
Rivero-Berti I, Rodenak-Kladniew B, Pérez AA, et al. Development of biocarrier of violacein controlled release for treatment of cancer. React Funct Polym 2019; 136: 122-30.
[http://dx.doi.org/10.1016/j.reactfunctpolym.2019.01.001]
[40]
Rivero-Berti I, Rodenak-Kladniew B, Onaindia C, et al. Assessment of in vitro cytotoxicity of imidazole ionic liquids and inclusion in targeted drug carriers containing violacein. RSC Advances 2020; 10: 29336-46.
[http://dx.doi.org/10.1039/D0RA05101B]
[41]
Enomoto K, Hosokawa K. Protein kinase inhibitor, method for producing the same, medicinal composition for treating cancer and reagent. JP2010126469 (A), 2010.
[42]
Xing X, Sun Y, Zhang C. Violacein and/or deoxyviolacein for promoting wound healing and hemoglutination. CN107865866 (A), 2018.
[43]
Paik SH, Kang HS, Jang IH, et al. The antiparasitic and antifungal agent containing violacein and the method of it. KR20060018386 KR100802494B, 2006.
[44]
Jaegon K, Kang HS, Soyoung K, et al. Insecticide and fungicide containing violacein, and their preparation method. KR20070088150 A, 2007.
[45]
Costa FTM, Justo GZ, Durán N, Nogueira PA, Lopes SCP. Uso da violaceina na forma livre ou encapsulada em sistemas polimericos como antimalárico (In Portugues). BR056399-0, 2005.
[46]
Costa FTM, Justo GZ, Durán N, Nogueira PA, Lopes SCP. Use of violacein, in free or encapsulated form in polymeric systems as antimalarial. BR0506399-0, 2020.
[47]
Asolkar R, Huang H, Koivunen M, Marrone P. Chromobacterium bioactive compositions and metabolites. US9187531 (B2), 2015.
[48]
Asolkar R, Nanmath J, Marrone P. Chromobacterium formulations, compositions, metabolites, and their uses. BR-112014009140-A2, US9259007-B2, 2016.
[49]
Aoki S, Nomura T. Production of natural antimicrobial antioxidant and its cosmetic formulation. JPH10139612 (A), 1998.
[50]
Durán N, De Azevedo MMM. Polymeric nanoparticle incorporating a compound with pharmaceutical or cosmetic properties, its process of obtaining and cosmetic or pharmaceutical composition containing the polymeric nanoparticles. BR0404306-5, 2004.
[51]
Meiring U, Lanzendoerfer G, Riedel H, et al. Cosmetic preparation, useful e.g. for the protection of skin and (semi)mucous membrane against bacteria and/or virus, comprises violacein dye in combination with lipophilic and/or hydrophilic substances. DE102005051869 (A1), 2007.
[52]
Hidachi K, Ueno M, Kishi H, et al. Cosmetics, pharmaceuticals, and quasi drugs containing violacein. JP2015105264 (A), 2015.
[53]
Wang YW, Xiao RZ. Use of natural pigment as nail polish pigment enabling to develop a healthy and environmentally friendly nail polish pigment. TW201720877A, TW1570191B, 2017.
[54]
Minbiole KPC, Harris R. Probiotic composition and process thereof. US8506952 B2, 2013.
[55]
Nomura T. Production of natural dye and dyeing with the dye. JPH06253864 (A), 1994.
[56]
Shirata A, Tsukamoto Y, Kato H, Hata T, Yasui H, Kojima A. Bluish purple pigment produced by bacterium and its use as dye or coloring additive JPH10113169 (A), 1998.
[57]
Hata T, Kato H, Kojima A, et al. Bluish purple pigment produced by bacterium and its use as dye or coloring additive. JPH10113169A, 1998.
[58]
Kato H, Hata T, Shirata A, Tsukamoto Y. Treatment for improving light resistance of bluish violet pigment. JPH 11152687 A, 1999.
[59]
Wan Z, Rozi AM, Bin MI, et al. A method for dyeing polyester fabrics using colorant extracted from Chromobacterium violaceum. MY150969-A, 2014.
[60]
Lee JH, Kwon JH, Lee CS, Mitchell RJ, Seong Y. A manufacturing method of violacein coated fiber and violacein coated fiber manufactured thereby. KR20180056295 (A), 2018.
[61]
Choi SY, Lim S, Cho G, et al. Chromobacterium violaceum delivers violacein, a hydrophobic antibiotic, to other microbes in membrane vesicles. Environ Microbiol 2020; 22(2): 705-13.
[http://dx.doi.org/10.1111/1462-2920.14888] [PMID: 31814287]
[62]
Gupta A, Reizman IMB, Reisch CR, Prather KLJ. Dynamic regulation of metabolic flux in engineered bacteria using a pathway-independent quorum-sensing circuit. Nat Biotechnol 2017; 35(3): 273-9.
[http://dx.doi.org/10.1038/nbt.3796] [PMID: 28191902]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy