Title:Evaluation of Salivary Helicobacter pylori, Calcium, Urea, pH and flow rate in Hemodialysis patients.
VOLUME: 20
Author(s):Farshad Teimoori, Mehrdad Hajilooei, Hamidreza Abdolsamadi, Khadijeh Eslami, Abbas Moghimbeigi and Fatemeh Ahmadi- Motamayel*
Affiliation:General Dental Practitioner, Hamadan University of Medical Science, Hamadan, Medical School, Department of Immunology and Hematology , Hamadan University of Medical Sciences, Hamadan, Dental research Center, Department of Oral medicine, Hamadan University of Medical Science, Hamadan, Medical School, Department of Nephrology , Hamadan University of Medical Sciences, Hamadan, Department of Biostatistics and Epidemiology, School of Public Health, Alborz University of Medical Sciences, Karaj, Research Center for Molecular Medicine and Dental Research Center, Department of Oral medicine, Hamadan University of Medical Science, Hamadan
Keywords:calcium, chronic renal failure, Helicobacter pylori, saliva, urea.
Abstract:Background: Helicobacter pylori infection identified as a major cause of stomach ulcers, chronic inflammation
and gastric cancer in hemodialysis patients. Dialysis also leads to changes in the composition and flow of saliva.
Objective: The aim of this study was to investigate the salivary Helicobacter pylori infection, Calcium, Urea, pH and flow
rate in hemodialysis patients in comparison to the healthy control group.
Method: In this study 48 hemodialysis patients and 48 healthy subjects were compared. The prevalence of Helicobacter pylori infection was determined by PCR method. Calcium, Urea, pH, salivary flow and gastrointestinal complications in both
groups were measured and compared.
Results: Prevalence of Helicobacter pylori was 12.48 (25.0%) in the study group and 2.48 (4.2%) in the controls. (P=0.000).
Urea, calcium and pH were significantly higher in the patient group .The mean salivary flow rate decreased significantly in
the patient group. 58.3% of patients group had gastrointestinal complications.
Conclusion: Oral cavity as an important external source of Helicobacter pylori may play an important role in gastrointestinal problems of hemodialysis patients. Helicobacter pylori, Urea, calcium and pH were significantly higher in the patient
group .Chronic renal failure can increase pH, urea and calcium in saliva and decrease salivary flow rate.
