Burns, mechanical injuries, skin defects, poor wound healing and scars caused by chronic diseases are serious
clinical issues that affect millions of people around the world. Hyaluronic acid (HA) is one of the main components of
extracellular matrix, which is widely distributed in human body. Because of its unique physical and chemical properties and
diversity of physiological functions, hyaluronic acid is widely used in tissue engineering and regenerative medicine. This
paper reviews the application of HA and HA based scaffolds in the regeneration and repair of skin tissue, as well as the
application of HA in the fields of skin filler, wound healing, beauty, etc.