Abstract
Foot infections, being one of the major complications, account for nearly 15% of people with diabetes, and increase their risk for amputation in lower extremities. Though various factors contribute to the development of diabetic foot infection, poor glycemic control poses a greater risk paving the way for a number of micro-organisms to colonize the wound.
In order to restore the lost granulation tissue at the ulcer site, the prime aim should not only be attaining glycemic control but also must focus on performing culture by clinically differentiating the stage of infection as well as to manage or control the infection by selecting a rational empiric antibiotic regimen, amidst the uncertainty that exists in choosing best antimicrobial therapy in emerging multi-drug resistance worldwide. This review mainly analyzes that although among the existence of various undefined microbiome being prevalent in causing diabetic foot infections, how the current trend of antibiotics in use aids in treating foot infections in diabetes.Keywords: Diabetic foot infections, matrix metallo-proteinases, wagner classification, methicillin resistant Staphylococcusaureus, antimicrobial therapy, microbiome.
Infectious Disorders - Drug Targets
Title:A Review on the Current Principles of Antibiotic Therapy for Diabetic Foot Infection
Volume: 21 Issue: 5
Author(s): Sainath Prasanna Bharathi and Sathesh Kumar Sukumaran*
Affiliation:
- School of Pharmaceutical Sciences, Vels Institute of Science, Technology and Advanced Studies (VISTAS), Chennai 600117, Tamilnadu,India
Keywords: Diabetic foot infections, matrix metallo-proteinases, wagner classification, methicillin resistant Staphylococcusaureus, antimicrobial therapy, microbiome.
Abstract:
Foot infections, being one of the major complications, account for nearly 15% of people with diabetes, and increase their risk for amputation in lower extremities. Though various factors contribute to the development of diabetic foot infection, poor glycemic control poses a greater risk paving the way for a number of micro-organisms to colonize the wound.
In order to restore the lost granulation tissue at the ulcer site, the prime aim should not only be attaining glycemic control but also must focus on performing culture by clinically differentiating the stage of infection as well as to manage or control the infection by selecting a rational empiric antibiotic regimen, amidst the uncertainty that exists in choosing best antimicrobial therapy in emerging multi-drug resistance worldwide. This review mainly analyzes that although among the existence of various undefined microbiome being prevalent in causing diabetic foot infections, how the current trend of antibiotics in use aids in treating foot infections in diabetes.Export Options
About this article
Cite this article as:
Bharathi Prasanna Sainath and Sukumaran Kumar Sathesh *, A Review on the Current Principles of Antibiotic Therapy for Diabetic Foot Infection, Infectious Disorders - Drug Targets 2021; 21 (5) : e270421188440 . https://dx.doi.org/10.2174/1871526520999201126203738
DOI https://dx.doi.org/10.2174/1871526520999201126203738 |
Print ISSN 1871-5265 |
Publisher Name Bentham Science Publisher |
Online ISSN 2212-3989 |
- Author Guidelines
- Graphical Abstracts
- Fabricating and Stating False Information
- Research Misconduct
- Post Publication Discussions and Corrections
- Publishing Ethics and Rectitude
- Increase Visibility of Your Article
- Archiving Policies
- Peer Review Workflow
- Order Your Article Before Print
- Promote Your Article
- Manuscript Transfer Facility
- Editorial Policies
- Allegations from Whistleblowers
- Announcements
Related Articles
-
Aspirin and Other Non-Steroidal Anti-Inflammatory Drugs as Cyclooxygenase Inhibitors: State of the Art, Barriers and Perspectives
Current Computer-Aided Drug Design TNF alpha Inhibition as Treatment Modality for Certain Rheumatologic and Gastrointestinal Diseases
Endocrine, Metabolic & Immune Disorders - Drug Targets Prevalence of Obesity, Hypertension, Diabetes, and Metabolic Syndrome and Its Cardiovascular Complications
Current Hypertension Reviews Redox Signaling Pathways Involved in Neuronal Ischemic Preconditioning
Current Neuropharmacology Antioxidant Activity of Plant Phenols: Chemical Mechanisms and Biological Significance
Current Organic Chemistry Roles of Insulin Resistance, Endothelial Dysfunction and Lifestyle Changes in the Development of Cardiovascular Disease in Diabetic Patients
Current Drug Targets Renal Ischemia: How Commonly Does it Cause Renal Failure?
Current Hypertension Reviews Atherogenic Index of Plasma in Women with Rheumatoid Arthritis and Systemic Lupus Erythematosus: A 10-Year Potential Predictor of Cardiovascular Disease
Current Rheumatology Reviews Contemporary Risk Assessment and Cardiovascular Outcomes in Peripheral Arterial Disease
Cardiovascular & Hematological Disorders-Drug Targets Thrombotic Microangiopathies: Towards a Pathophysiology-Based Classification
Cardiovascular & Hematological Disorders-Drug Targets Endothelial Dysfunction: Methods of Assessment and Application to Hypertension
Current Pharmaceutical Design Therapeutic Options and Emerging Alternatives for Multidrug Resistant Staphylococcal Infections
Current Pharmaceutical Design Systemic Sclerosis: Clinical Manifestations
Current Rheumatology Reviews Novel Variants of DOCK8 Deficiency in a Case Series of Iranian Patients
Endocrine, Metabolic & Immune Disorders - Drug Targets Diabetes and Vascular Disease: Basic Concepts of Nitric Oxide Physiology, Endothelial Dysfunction, Oxidative Stress and Therapeutic Possibilities
Current Vascular Pharmacology Platelets in Atherothrombosis: New and Evolving Roles
Current Pharmaceutical Design Genome-Wide Association Studies: Is there a Genotype for Cognitive Decline in Older Persons with Type 2 Diabetes?
Current Pharmaceutical Design Vitamin D Insufficiency and Diabetes Risks
Current Drug Targets Targeting Apelinergic System in Cardiometabolic Disease
Current Drug Targets Fish Oils and Vascular Disease Prevention: An Update
Current Medicinal Chemistry