MicroRNA Regulation of TRAIL in Renal Carcinoma: Tiny Juggernauts at Work

(E-pub Ahead of Print)

Author(s): Zeeshan Javed, Khushbukhat Khan, Haleema Sadia, Shahid Raza, Javad Sharifi-Rad*, William C. Cho*

Journal Name: Current Molecular Pharmacology

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Renal carcinoma (RC) is the ninth most prevalent cancer in men. Advancements in high throughput technology have begun to scratch the surface of the complex landscape of renal cancer. Development, progression, invasion and metastasis are the key mechanism modulated by the microRNAs. Recent pieces of evidence have delineated the role of these micro steering wheels in the regulation of vital processes of RC biology, therefore miRNAs can be implemented as a new therapeutic target for RC. MicroRNAs also negatively affect the process of apoptosis in cancer cells leading to their survival and growth. The role of dysregulated microRNAs in hindering the TRAIL-mediated apoptotic pathway is also known. Therapeutic interventions targeting tumor-suppressive microRNAs to promote apoptosis through extrinsic/intrinsic pathways seem a promising approach for advanced stage and metastatic renal cancers. This review aims to discuss renal carcinoma-specific microRNAs and their role in the TRAIL pathway and also shed light on the distinguished microRNAs that could serve as a diagnostic biomarker and therapeutic targets for this cancer.

Keywords: MicroRNA, trail, renal carcinoma, therapeutic Targets, anti-apoptotic proteins, RNA moleculesMicroRNA, trail, renal carcinoma, therapeutic Targets, anti-apoptotic proteins, RNA molecules

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(E-pub Ahead of Print)
DOI: 10.2174/1874467213999201124124649
Price: $95