Abstract
Supramolecular compounds are capable of undergoing various non-covalent interactions with other molecules like host-guest chemistry, controlled encapsulation, hydrophobic interactions, a variety of delivering strategies, electron affinity induced interactions, etc. These properties of supramolecular compounds make them attractive to be effective drug carriers. This review will describe in detail the recent interesting reports on the structure-activity relationship of supramolecular compounds in drug delivery. The supramolecular compounds considered are cyclodextrins, cucurbiturils, avidin, biotin, rotaxanes, viologens, and dendrimers. Studying the opportunities given by these supramolecular compounds in drug delivery will pave the way for novel efficient drug delivery systems for the future.
Keywords: Supramolecular compounds, drug delivery, structure activity relationship, cyclodextrin, cucurbituril, avidin, biotin, rotaxane, viologen, dendrimer.
Mini-Reviews in Organic Chemistry
Title:Structure-Activity Relationship of Supramolecular Compounds in Drug Delivery
Volume: 18 Issue: 7
Author(s): P. Rajalakshmi, Daniel N. Peter, Jesu Johnson S. and Nallamuthu Ananthi*
Affiliation:
- Department of Chemistry, Karunya Institute of Technology and Sciences, Coimbatore -641114, Tamil Nadu,India
Keywords: Supramolecular compounds, drug delivery, structure activity relationship, cyclodextrin, cucurbituril, avidin, biotin, rotaxane, viologen, dendrimer.
Abstract: Supramolecular compounds are capable of undergoing various non-covalent interactions with other molecules like host-guest chemistry, controlled encapsulation, hydrophobic interactions, a variety of delivering strategies, electron affinity induced interactions, etc. These properties of supramolecular compounds make them attractive to be effective drug carriers. This review will describe in detail the recent interesting reports on the structure-activity relationship of supramolecular compounds in drug delivery. The supramolecular compounds considered are cyclodextrins, cucurbiturils, avidin, biotin, rotaxanes, viologens, and dendrimers. Studying the opportunities given by these supramolecular compounds in drug delivery will pave the way for novel efficient drug delivery systems for the future.
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Cite this article as:
Rajalakshmi P. , Peter N. Daniel , S. Johnson Jesu and Ananthi Nallamuthu *, Structure-Activity Relationship of Supramolecular Compounds in Drug Delivery, Mini-Reviews in Organic Chemistry 2021; 18 (7) . https://dx.doi.org/10.2174/1570193X17999201123212536
DOI https://dx.doi.org/10.2174/1570193X17999201123212536 |
Print ISSN 1570-193X |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6298 |
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