Micro-RNAs (miRNA) are short non-coding sequences involved in the biological regulatory process. The miRNA
shows a unique expression in diseases resulting in the pathogenesis. Identifying the novel compounds are interesting
during this process. The miRNA is a biomarker that helps to find the early stage of cancer disease through pathogenesis.
Azobenzene and pyrazole are the novel compounds having a cytotoxic effect on cancer cells. These novel compounds are
molecular probe used in breast cancer therapy. The viral-based systems have few limitations such as toxicity and immunogenicity.
So, the non-viral based lipoplex and polyplex systems are attractive due to no size limitations for the transfection
of micro RNAs. The conventional drug delivery systems are having a large size and low drug efficacy at the target site. The
nanoparticles prepared by nanoprecipitation methods are attractive in cancer therapy. Thus, the miRNA acts as a powerful
tool and is used to identify the drug target in cancer therapy.
Keywords: micro RNA, drug target, bio-marker, drug discovery, drug delivery, small molecules, cancer therapy.
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