Anti-Cancer and Anti-Bacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles

Title:Anti-Cancer and Anti-Bacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles

Volume: 24 Issue: 10

Author(s): Hashem Yaghoubi*, Amin Izadpanah*, Shahla Nedaei, Hossein Akbari, Elmira Mikaeiliagah, Ricardo Mostany, Bysani Chandrasekar, Eckhard Alt and Reza Izadpanah

Affiliation:

• Department of Biology, Ardabil Branch, Islamic Azad University, Ardabil,Iran

• Applied Stem Cell Laboratory, Medicine/Heart and Vascular Institute, Department of Medicine, The Tulane University School of Medicine, New Orleans, Louisiana,United States

Keywords: Silver nanoparticles, Terfezia boudieri, cancer, green synthesis, antibacterial, infections agents.

Abstract:

Background: The use of nanoparticles has markedly increased in biomedical sciences. The silver nanoparticles (AgNPs) have been investigated for their applicability to deliver chemotherapeutic/antibacterial agents to treat cancer or infections disease. However, the existing chemical and physical methods of synthesizing AgNPs are considered inefficient, expensive and toxic.

Methods: Natural products have emerged as viable candidates for nanoparticle production, including the use of Terfezia boudieri (T. boudieri), a member of the edible truffle family. Accordingly, our goal was to synthesize AgNPs using an aqueous extract of T. boudieri (green synthesized AgNPs). Since certain infectious agents are linked to cancer, we investigated their potential as anti-cancer and antibacterial agents.

Results: The synthesis of AgNPs was confirmed by the presence of an absorption peak at 450nm by spectroscopy. The physico-chemical properties of green synthesized AgNPs were analyzed by UV-Vis, FT-IR, XRD, SEM, and TEM. In addition, their potential to inhibit cancer cell (proliferation and the growth of infectious bacteria were investigated.

Conclusion: The size of nanoparticles ranged between 20-30nm. They exerted significant cytotoxicity and bactericidal effects in a concentration and time-dependent manner compared to T. boudieri extract alone. Interestingly, the synthesis of smaller AgNPs was correlated with longer synthesis time and enhanced cytotoxic and bactericidal properties.

Cite this article as:

Yaghoubi Hashem *, Izadpanah Amin *, Nedaei Shahla , Akbari Hossein , Mikaeiliagah Elmira , Mostany Ricardo , Chandrasekar Bysani , Alt Eckhard and Izadpanah Reza , Anti-Cancer and Anti-Bacterial Effects of Terfezia boudieri-Derived Silver Nanoparticles, Combinatorial Chemistry & High Throughput Screening 2021; 24 (10) . https://dx.doi.org/10.2174/1386207323999201117113401