Development and Biocompatibility Analysis of NBD Peptide Sustained-release Microsphere Scaffold Nanoparticle SP-Sr-CaS/NBD

(E-pub Ahead of Print)

Author(s): Xue Li, Lei Wang, Changbing Wang, Caixia Tan, Xifaofang Liu, Yongzhan Zhu*

Journal Name: Current Drug Delivery

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In clinical treatment, it is difficult to carry out effective bone tissue transplantation and anti-inflammatory treat-ment at the same time due to bone defects and osteomyelitis where the tissue is contaminated or infected. As a downstream target of TNF-α, NF-κB has an inhibition effect on the proliferation and differentiation of cells surrounding the lesion. As a negative effect, it leads to slowing of bone growth and development. In this study, the small molecule NBD polypeptide and bone conduction matrix Sr-CaS are microsphere-formed to prepare Sr-CaS, NBD drug-loaded sustained-release micro-spheres, in order to achieve a Sr-CaS/NBD peptide drug-loaded sustained release microsphere scaffold material (SP-Sr-CaS/NBD). We prepared the microspheres and optimized the production process to obtain particles with stable morphologi-cal properties and sustained release properties. In vitro experiments demonstrated that SP-Sr-CaS/NBD can reduce TNF-α-induced cell growth inhibition, caspase-3 activity and NF-κB transcriptional activation as the function of continuous NBD peptide dosing regimen. Also, the introduction of Sr-CaS matrix potentiate microspheres to promote cell proliferation and provides a basis to become a hopeful used 3D bone scaffold material in the future.

Keywords: NBD, PLGA, Calcium sulfate, Osteomyelitis, Microsphere, Scaffold materials.

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(E-pub Ahead of Print)
DOI: 10.2174/1567201817999201116154935
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