Coumarins as Potential Anti-drug Resistant Cancer Agents: A Mini Review

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Author(s): Gangqiang Wang, Shaofa Sun, Bin Wu, Jikai Liu*

Journal Name: Current Topics in Medicinal Chemistry

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Cancer is the main cause of death, and the emergence of resistance by cancer cells towards existing anticancer agents is one of the major problems for effective chemotherapy, creating a great demand for the development of novel anticancer drugs. Coumarins, abundantly found in nature, constitute an important class of pharmacological agents pos-sessing physiological activities. The mechanism investigations elucidated that coumarins could lead to self-programmed cancer cell death (apoptosis) via different mechanisms, thereby coumarin-based derivatives possess potential activity against various forms of cancers including drug-resistant even multidrug-resistant cancers. This review article describes the recent progress in the discovery, structural modification, structure-activity relationship, and mechanism of action studies of cou-marin-based derivatives with potential activity against drug-resistant cancers, covering articles published between 2010 and 2020.

Keywords: coumarin; natural product; hybrid compounds; cancer; drug resistance; mechanism of action

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(E-pub Ahead of Print)
DOI: 10.2174/1568026620999201113110041
Price: $95

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