Background: There is moderate-to-high evidence that the Mediterranean diet prevents increases in body weight
and waist circumference in non-obese individuals but less is known about its effects in subjects with overweight and obesity.
The present study was focused on exploring the cross-sectional association among the adherence to Mediterranean diet and
the most commonly used variables of metabolic and cardiovascular risk factors in a cohort of overweight subjects from a
typical Mediterranean region, Apulia, in Southern Italy.
Methods: The study was performed in a cohort of 1214 individuals, all with overweight or obesity but no other clinical condition.
We investigated the association among adherence to Mediterranean diet, assessed with the PREDIMED score, and
anthropometric parameters [namely body mass index (BMI), WC, waist to height ratio (WHtR) and neck circumference
(NC)], fasting serum levels of glucose, insulin, uric acid and lipids (triglycerides, total cholesterol, HDL cholesterol and
LDL cholesterol), and blood pressure and insulin resistance, measured by HOMA-IR.
Results:The waist to height ratio was negatively associated to a PREDIMED score ≥7 (p<0.04), whereas HDL cholesterol
was positively associated to a PREDIMED score ≥7 (p<0.04)
Conclusion: This study suggests that body fat distribution and HDL-cholesterol are the parameters most strongly influenced
by MedDiet in Apulian subjects.