Distribution Characteristics of ANA and ANCA in Patients with Hyperthyroidism

(E-pub Ahead of Print)

Author(s): Chunhua Xun*

Journal Name: Endocrine, Metabolic & Immune Disorders - Drug Targets
Formerly Current Drug Targets - Immune, Endocrine & Metabolic Disorders


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Abstract:

Background: Antinuclear antibody( ANA) and Antineutrophil autoantibodies(ANCA) are often used as markers for diagnosis of autoimmune diseases. In clinical practice, we found that ANA and ANCA were often occured in sera of pa-tients with hyperthyroidism.

Objective: To discover the positive feature of anti-nuclear antibodies(ANA) and anti-neutrophil cytoplasmic antibodies(ANCA) in hyperthyroidism

Materials and methods: Sera samples from 171 patients with hyperthyroidism and 50 healthy controls, ANA and ANCA were detected with indirect immunofluorescence(IIF) method.

Results: ANA and ANCA positive rates were higher in hyperthyroidism (33.9% and 29.2%,respectively )than that in con-trol(4.0% and 2.0%,respectively), the low titer (≤1:320)of ANA was dominated (86.2%) in 58 hyperthyroidism patients with positive ANA, the major pattern was homogeneous (48.3%) and speckled patterns (48.3%); the low titer (≤1:32) of ANCA was dominated(64.6%) in 50ANCA positive samples and the major pattern was perinuclear (p)ANCA(96%).

Conclusion: The positive rates of ANA and ANCA were increased and mainly appeared low titer in hyperthyroidism, which supplement laboratory characteristics of hyperthyroidism.

Keywords: Immunofluorescence, hyperthyroidism, ANA, ANCA, distribution characteristics, autoantibody.

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Article Details

Published on: 11 November, 2020
(E-pub Ahead of Print)
DOI: 10.2174/1871530320999201111160420
Price: $95

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