Nano-Lipid-carriers for the Treatment of Vitiligo: A Recent Update, Pathophysiology and Mechanism of Drug Delivery

(E-pub Ahead of Print)

Author(s): Supratim Das, Sukhbir Kaur*

Journal Name: Current Molecular Pharmacology


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Abstract:

Background: Vitiligo is an auto-immune disease with white-coloured disfiguring patches or spots on the skin surface. It is highly prevalent in several corners of the world. This disease spreads in different age groups.

Aim: The main aim of this review is to provide overview of Pathophysiology and Lipid-based nano-carriers for the treatment of vitiligo.

Methods: The conventional delivery systems available are having limited efficacy due to the less retention of the drug in the epidermal layer where melanocytes resides. In order to overcome these issues, delivery system with Lipid-based nano-carriers for the treatment of vitiligo were proven to better as per the literature explored.

Results: This review summarizes the pathophysiology along with novel Lipid-based nano-carriers for the treatment of vitiligo are described well.

Conclusion: Though various treatment regimens are present for the disease, nano-lipid carrier systems are gaining importance hugely now-a-days, due to their high effectivity in topically acting on the target site. Nano-lipid carrier systems such as liposomes, ethosomes, transethosomes and transferosomes can be said to be at the top of the list in acting effectively against vitiligo or several other topical diseases.

Keywords: Vitiligo; lipid vesicular systems; liposome; ethosome; transethosome; transferosome

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1874467213999201109220714
Price: $95

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