Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting
the interest of many scientists in drug discovery.
Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme
Results and Discussion: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed
significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2),
but cytotoxic effect on all tested cancer cell lines could not be observed.
Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial
properties without cytotoxic effect, which could make it a promising active component.