Title:Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules
VOLUME: 17
Author(s):Aslıhan Kurt-Kızıldoğan, Çiğdem Otur, Can Yılmaz, Sevki Arslan, Dogukan Mutlu, Arif Kivrak*, Muheb Algso, Abdussamet Kayhan, Doğan Çetin and Metin Konus*
Affiliation:Department of Agricultural Biotechnology, Faculty of Agriculture, Ondokuz Mayıs University, 55139 Samsun,, Department of Agricultural Biotechnology, Faculty of Agriculture, Ondokuz Mayıs University, 55139 Samsun,, Department of Molecular Biology and Genetics, Faculty of Sciences, Van Yüzüncü Yil University, 65080, Van,, Department of Biology, Faculty of Arts and Sciences, Pamukkale University, 20100, Denizli,, Department of Biology, Faculty of Arts and Sciences, Pamukkale University, 20100, Denizli,, Department of Chemistry, Faculty of Sciences, Van Yüzüncü Yil University, Van, 65080,, Department of Chemistry, Faculty of Sciences, Van Yüzüncü Yil University, Van, 65080,, Department of Molecular Biology and Genetics, Faculty of Sciences, Van Yüzüncü Yil University, 65080, Van,, Department of Molecular Biology and Genetics, Faculty of Sciences, Van Yüzüncü Yil University, 65080, Van,, Department of Molecular Biology and Genetics, Faculty of Sciences, Van Yüzüncü Yil University, 65080, Van
Keywords:Indole, heteroaromatic compounds, antioxidant, cytotoxicity, antimicrobial, small molecules.
Abstract:Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting
the interest of many scientists in drug discovery.
Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme
activity test.
Results and Discussion: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed
significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2),
but cytotoxic effect on all tested cancer cell lines could not be observed.
Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial
properties without cytotoxic effect, which could make it a promising active component.
