Abstract
Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.
Objective: The aim of this review was to provide an overview of the quinones that have become drugs for several therapeutic applications.
Methods: We have comprehensively and critically discussed all the information available in the literature about quinone-based drugs.
Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses.
Conclusion: A number of studies related to quinone drugs for different pharmaceutical uses show that the interest in new applications is still increasing in recent years.
Keywords: Atovaquone, buparvaquone, parvaquone, mitomycins, doxorubicin, valrubicin, mitoxantrone.
Medicinal Chemistry
Title:Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry
Volume: 17 Issue: 10
Author(s): Vitor F. Ferreira*, Alcione S. de Carvalho, Patricia G. Ferreira, Carolina G.S. Lima and Fernando de C. da Silva
Affiliation:
- Universidade Federal Fluminense, Faculdade de Farmacia, Departamento de Tecnologia Farmaceutica, Niteroi, 24241-000, RJ,Brazil
Keywords: Atovaquone, buparvaquone, parvaquone, mitomycins, doxorubicin, valrubicin, mitoxantrone.
Abstract:
Background: Several quinones are on the pharmaceutical market as drugs for the treatment of several diseases.
Objective: The aim of this review was to provide an overview of the quinones that have become drugs for several therapeutic applications.
Methods: We have comprehensively and critically discussed all the information available in the literature about quinone-based drugs.
Results: In this review, the various aspects of the chemistry and biochemistry of these drugs are highlighted, including their repositioning, drug combination and their new uses.
Conclusion: A number of studies related to quinone drugs for different pharmaceutical uses show that the interest in new applications is still increasing in recent years.
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Cite this article as:
Ferreira F. Vitor *, de Carvalho S. Alcione , Ferreira G. Patricia, Lima G.S. Carolina and de C. da Silva Fernando , Quinone-Based Drugs: An Important Class of Molecules in Medicinal Chemistry, Medicinal Chemistry 2021; 17 (10) . https://dx.doi.org/10.2174/1573406416666201106104756
DOI https://dx.doi.org/10.2174/1573406416666201106104756 |
Print ISSN 1573-4064 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-6638 |
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