Title:Bioactive Isolates of Morus Species as Antibacterial Agents and their in-silico Profiling
VOLUME: 17
Author(s):Aditya Rao*, Venugopal T.M, Jayanna N.D, Paramesha Mahadevappa and Ramesh C.K
Affiliation:Department of Biotechnology, Kuvempu University, Sahyadri Science College campus, Shivamogga, Karnataka, Department of Microbiology, Kuvempu University, Sahyadri Science College campus, Shivamogga, Karnataka, Department of Chemistry, Kuvempu University, Sahyadri Science College campus, Shivamogga, Karnataka, Department of Plant Cell Biotechnology, CSIR-CFTRI, Mysore, Karnataka, Department of Biotechnology, Kuvempu University, Sahyadri Science College campus, Shivamogga, Karnataka
Keywords:Bacteriostatic, Docking, Natural products, CHARMm, Glucosamine-6-phosphate synthase, Morus.
Abstract:Background: The genus Morus is one of the rich sources of phytomedicine and considered as a beneficial natural
source for the drugs with potential antimicrobial effect under the traditional system of medicine.
Introduction: In the present study, three bioactive compounds were isolated from the leaves of two species of genus Morus
and their antibacterial effect against selective pathogens were assessed.
Methods: The inhibitory effects of the three molecules isolated were assessed for their minimum inhibition concentration
(MIC) and minimum bactericidal concentration (MBC) against selected pathogens. The in-silico studies provided the toxicity profile and the binding interactions with glucosamine-6-phosphate synthase for all the isolates.
Results and Discussion: Among the three compounds tested, cathafuran-B showed prominent bacteriostatic and bactericidal
effect which is supported by the results of in-silico analysis suggesting cathafuran-B could be a potential glucosamine-6-
phosphate synthase inhibitor.
Conclusion: The biomolecule isolated from less explored Morus laevigata exhibiting higher antibacterial effect among the
compounds tested warranted opening a new prospect in phytomedicinal research in exploring its pharmacological properties
and lowering the utilization load present on highly explored Morus alba.
