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Current Protein & Peptide Science

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ISSN (Print): 1389-2037
ISSN (Online): 1875-5550

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Review Article

Applications of iTRAQ and TMT Labeling Techniques to the Study of Neurodegenerative Diseases

Author(s): Kelu Li, Zichao Chen, Yonggang Zhang and Xinglong Yang*

Volume 21, Issue 12, 2020

Page: [1202 - 1217] Pages: 16

DOI: 10.2174/1389203721666201103085704

Price: $65

Abstract

Neurodegenerative diseases are caused by progressive lesions or loss of specific nerve cells, which endanger human health. However, the mechanism by which neurodegeneration manifests remains unclear. Proteomics can shed light on this question as well as help establish diagnostic standards and discover new drug targets. The power of proteomics for understanding neurodegenerative diseases has increased substantially with the application of iTRAQ and TMT labeling techniques. This review focuses on progress in these labeling techniques and their applications in neurodegeneration research.

Keywords: Neurodegenerative diseases, iTRAQ, TMT, proteomics, quantitative neuroproteomics, neuro-imaging.

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