Relationship with Metalloproteinase 13, E-cadherin, Homocysteine and co factors folic acid and vitamin B12 in patients diagnosed with prostate cancer

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Author(s): Thaís Moura Gascón*, Beatriz Gascón Lourenço, Edimar Cristiano Pereira, Beatriz Alves da Costa Aguiar, Glaucia Luciano Veiga, Flavia de Sousa Gehrke, Fernando Adami, Fernando Luiz Affonso Fonseca

Journal Name: Current Enzyme Inhibition

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Abstract:

Introduction: Prostate cancer (Pc) is the most frequent neoplasia in men and the second cause deaths in Brazil.

Objective: Analyze the interactions and biologicals responses of Pc oxidative stress and prostate-specific antigen (PSA) E-cadherin and MMP-13. Demonstrate whether the increase of the amount of the form of E-cadherin found in the plasma of Pc patients, correlates with decrease of the PSA.

Methods: Samples were obtained through peripheral venipuncture to analyse parameters of biomarkers pc as PSA, E-cadherin, MMP-13, Homocysteine, Folic acid, Vitamin B12, Testosterone T and free following the patients diagnosis, 3 and 6 months during their treatment to analyze the biological responses of Pc oxidative stress.

Results: The analysis was performed by using immunoenzymatic assay. Statistical data processed through Excel in Windows Vista and analyzed through the Shapiro-wilk Test, ANOVA, and Spearman Test. An increase in concentration of E-cadherin (p = 0.02), as a decrease in concentration of PSA (p < 0.001), total testosterone (p < 0.001) and free testosterone (p = 0.02) was observed the treatment period without significant alterations in the remaining markers for either of the periods.

Discussion: It was concluded during treatment of men diagnosed with pc is an increase concentration of plasmatic E-cadherin, which are negatively correlated with the concentrations of folic acid (-0,03 (0,87) rs (p). It was observed that the levels of hcy are positively correlated with concentrations of total testosterone and a negative correlation . Vitamins B12 remained within the parameters of normality during the entire study.

Conclusion: The plasma levels of E-cadherin increased during chemotherapy treatment. However, as P.S.A levels and free and total testosterone levels decreased. The attenuation in folic acid during the state of development can assist treatment, once it blocks abnormal cellular replication, nevertheless it can affect the cycle of cellular methylation.

Keywords: Prostate cancer, Metalloproteinase-13, E-cadherin, Homocysteine, Biomarkers.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1573408016999201026195354
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