Review on the Synthetic Methods of Biologically Potent Benzoxazole Derivatives

Title:Review on the Synthetic Methods of Biologically Potent Benzoxazole Derivatives

Volume: 18 Issue: 6

Author(s): Subramaniyan Arulmurugan, Helen P. Kavitha*Jasmine P. Vennila

Affiliation:

• Department of Chemistry, SRM Institute of Science and Technology, Ramapuram Campus, Bharathi Salai, Ramapuram, Chennai, Tamil Nadu,India

Keywords: Benzoxazole, synthesis, antimicrobial activity, anti-inflammatory activity, anticancer activity, antitubercular activity.

Abstract: Benzoxazole compounds have an important and broad range of biological activities. The benzoxazole and its substituted derivatives possess antimicrobial, antitumor, anti-inflammatory, antihistaminic, anti-parasitic, herbicidal, anti-allergic, anti-helmintic, anti-tubercular, anticonvulsant, hypoglycaemic, HIV-1 reverse transcriptase inhibitor and insecticidal activities. It has also been shown to have a binding affinity to Aβ42 fibrils. Such complex biological uses of benzoxazole compounds have inspired new efforts to find new derivatives with improved biological activity and different applications in the pharmaceutical industry. Due to outstanding relevance of this structure, the purpose of this analysis is to highlight aspects published in recent years (2000-2020) on the chemistry and biological activity of benzoxazoles.

Cite this article as:

Arulmurugan Subramaniyan , Kavitha P. Helen *, Vennila P. Jasmine , Review on the Synthetic Methods of Biologically Potent Benzoxazole Derivatives, Mini-Reviews in Organic Chemistry 2021; 18 (6) . https://dx.doi.org/10.2174/1570193X17999201020231359