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Coronaviruses

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ISSN (Print): 2666-7967
ISSN (Online): 2666-7975

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Perspective Article

Combination of Hydroxychloroquine, Melatonin and Mercaptopurine as a Possible Intervention for Prophylaxis and Treatment of Novel COVID-19 Infection

Author(s): Gyan Vardhan, Vikas Kumar, Megha Agrawal and Puneet Dhamija*

Volume 2, Issue 4, 2021

Published on: 16 October, 2020

Page: [415 - 418] Pages: 4

DOI: 10.2174/2666796701999201016154957

Abstract

Background: COVID-19 has been declared as a pandemic recently and has caused many deaths worldwide. Till date, no effective drug or vaccine is available against SARS-CoV-2. There is an urgent need to find effective alternative preventive and treatment strategies to deal with the SARS-CoV- 2 outbreak.

Objective: This communication proposes a new potential drug combination (repurposed) for prophylaxis and treatment of SARS-CoV-2.

Methods and Materials: We performed a brief review of literature on a combination of Hydroxychloroquine, Melatonin and Mercaptopurine for prophylaxis and treatment of Novel COVID-19 infection and also assessed their possible mechanism of action against SARS-CoV-2.

Observation: Proposed combination seems to be safe, and the target is unlikely to develop resistance to this combination.

Conclusion: This scientific review proposes potential candidate repurposed drugs and potential drug combinations targeting 2019-nCoV/SARS-CoV-2.

Keywords: Novel COVID-19, Hydroxychloroquine, Melatonin, Mercaptopurine, coronavirus, Prophylaxis.

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