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Current Genomics

Editor-in-Chief

ISSN (Print): 1389-2029
ISSN (Online): 1875-5488

Review Article

DNA Methylation Markers in Lung Cancer

Author(s): Yoonki Hong and Woo Jin Kim*

Volume 22, Issue 2, 2021

Published on: 13 October, 2020

Page: [79 - 87] Pages: 9

DOI: 10.2174/1389202921999201013164110

Price: $65

Abstract

Lung cancer is the most common cancer and the leading cause of cancer-related morbidity and mortality worldwide. As early symptoms of lung cancer are minimal and non-specific, many patients are diagnosed at an advanced stage. Despite a concerted effort to diagnose lung cancer early, no biomarkers that can be used for lung cancer screening and prognosis prediction have been established so far. As global DNA demethylation and gene-specific promoter DNA methylation are present in lung cancer, DNA methylation biomarkers have become a major area of research as potential alternative diagnostic methods to detect lung cancer at an early stage. This review summarizes the emerging DNA methylation changes in lung cancer tumorigenesis, focusing on biomarkers for early detection and their potential clinical applications in lung cancer.

Keywords: Non-small-cell lung cancer, DNA methylation, biomarker, epigenetic, tumorigenesis, hypomethylation.

Graphical Abstract
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