Antioxidant and Anti-inflammatory Properties of Yttrium Oxide Nanoparticles: New Insights into Alleviating Diabetes

Kim    San    Tang
Abstract

Background: Diabetes mellitus is a metabolic disease that requires immediate attention. Oxidative stress that leads to the generation of reactive oxygen species is a contributing factor to the disease progression. Yttrium oxide nanoparticles (Y₂O₃ NPs) have a profound effect on alleviating oxidative damage.
Methods: The literature related to Y₂O₃ NPs and oxidative stress has been thoroughly searched using PubMed and Scopus databases and relevant studies from inception until August 2020 were included in this scoping review.
Results: Y₂O₃ NPs altered oxidative stress-related biochemical parameters in different disease models including diabetes.
Conclusion: Although Y₂O₃ NPs are a promising antidiabetic agent due to their antioxidant and anti- inflammatory properties, more studies are required to further elucidate the pharmacological and toxicological properties of these nanoparticles.
Keywords: Antioxidants, diabetes mellitus, inflammation, nanoparticles, oxidative stress, reactive oxygen species, yttrium oxide.
[1] 
Banerjee M, Vats P, Kushwah AS, Srivastava N. Interaction of antioxidant gene variants and susceptibility to type 2 diabetes mellitus. Br J Biomed Sci  2019; 76(4): 166-71.
[http://dx.doi.org/10.1080/09674845.2019.1595869] [PMID: 30900957] 
[2] 
Zimmet P, Alberti KG, Magliano DJ, Bennett PH. Diabetes mellitus statistics on prevalence and mortality: facts and fallacies. Nat Rev Endocrinol  2016; 12(10): 616-22.
[http://dx.doi.org/10.1038/nrendo.2016.105] [PMID: 27388988] 
[3] 
Tang KS. The current and future perspectives of zinc oxide nanoparticles in the treatment of diabetes mellitus. Life Sci  2019; 239117011
[http://dx.doi.org/10.1016/j.lfs.2019.117011] [PMID: 31669241] 
[4] 
Ennerfelt H, Voithofer G, Tibbo M, et al. Disruption of peripheral nerve development in a zebrafish model of hyperglycemia. J Neurophysiol  2019; 122(2): 862-71.
[http://dx.doi.org/10.1152/jn.00318.2019] [PMID: 31268813] 
[5] 
Chaudhury A, Duvoor C, Reddy Dendi VS, et al. Clinical review of antidiabetic drugs: implications for type 2 diabetes mellitus management. Front Endocrinol (Lausanne)  2017; 8: 6.
[http://dx.doi.org/10.3389/fendo.2017.00006] [PMID: 28167928] 
[6] 
Francescato MP, Stel G, Geat M, Cauci S. Oxidative stress in patients with type 1 diabetes mellitus: is it affected by a single bout of prolonged exercise? PLoS One  2014; 9(6)e99062
[http://dx.doi.org/10.1371/journal.pone.0099062] [PMID: 24905823] 
[7] 
Giacco F, Brownlee M. Oxidative stress and diabetic complications. Circ Res  2010; 107(9): 1058-70.
[http://dx.doi.org/10.1161/CIRCRESAHA.110.223545] [PMID: 21030723] 
[8] 
Tang KS, Tan JS. The protective mechanisms of polydatin in cerebral ischemia. Eur J Pharmacol  2019; 842: 133-8.
[http://dx.doi.org/10.1016/j.ejphar.2018.10.039] [PMID: 30385347] 
[9] 
Newsholme P, Cruzat VF, Keane KN, Carlessi R, de Bittencourt PI Jr. Molecular mechanisms of ROS production and oxidative stress in diabetes. Biochem J  2016; 473(24): 4527-50.
[http://dx.doi.org/10.1042/BCJ20160503C] [PMID: 27941030] 
[10] 
Fiorentino TV, Prioletta A, Zuo P, Folli F. Hyperglycemia-induced oxidative stress and its role in diabetes mellitus related cardiovascular diseases. Curr Pharm Des  2013; 19(32): 5695-703.
[http://dx.doi.org/10.2174/1381612811319320005] [PMID: 23448484] 
[11] 
Holzerová E, Prokisch H. Mitochondria: Much ado about nothing? How dangerous is reactive oxygen species production? Int J Biochem Cell Biol  2015; 63: 16-20.
[http://dx.doi.org/10.1016/j.biocel.2015.01.021] [PMID: 25666559] 
[12] 
Apostolova N, Victor VM. Molecular strategies for targeting antioxidants to mitochondria: therapeutic implications. Antioxid Redox Signal  2015; 22(8): 686-729.
[http://dx.doi.org/10.1089/ars.2014.5952] [PMID: 25546574] 
[13] 
Nimse SB, Pal D. Free radicals, natural antioxidants, and their reaction mechanisms. RSC Advances  2015; 5(35): 27986-8006.
[http://dx.doi.org/10.1039/C4RA13315C] 
[14] 
Panigrahy SK, Bhatt R, Kumar A. Reactive oxygen species: sources, consequences and targeted therapy in type 2 diabetes. J Drug Target  2017; 25(2): 93-101.
[http://dx.doi.org/10.1080/1061186X.2016.1207650] [PMID: 27356044] 
[15] 
Bagetta D, Maruca A, Lupia A, et al. Mediterranean products as promising source of multi-target agents in the treatment of metabolic syndrome. Eur J Med Chem  2020; 186111903
[http://dx.doi.org/10.1016/j.ejmech.2019.111903] [PMID: 31787360] 
[16] 
Morvaridzadeh M, Nachvak SM, Agah S, et al. Effect of soy products and isoflavones on oxidative stress parameters: A systematic review and meta-analysis of randomized controlled trials. Food Res Int  2020; 137109578
[http://dx.doi.org/10.1016/j.foodres.2020.109578] 
[17] 
Sepidarkish M, Akbari-Fakhrabadi M, Daneshzad E, et al. Effect of omega-3 fatty acid plus vitamin E Co-Supplementation on oxidative stress parameters: A systematic review and meta-analysis. Clin Nutr  2020; 39(4): 1019-25.
[http://dx.doi.org/10.1016/j.clnu.2019.05.004] [PMID: 31128941] 
[18] 
Faddladdeen KAJ. Ameliorating effect of pomegranate peel extract supplement against type 1 diabetes-induced hepatic changes in the rat: biochemical, morphological and ultrastructural microscopic studies. Folia Morphol (Warsz) 2020.
[http://dx.doi.org/10.5603/FM.a2020.0034] [PMID: 32207851] 
[19] 
Mohammed A, Islam MS. Antioxidant potential of Xylopia aethiopica fruit acetone fraction in a type 2 diabetes model of rats. Biomed Pharmacother  2017; 96: 30-6.
[http://dx.doi.org/10.1016/j.biopha.2017.09.116] [PMID: 28963948] 
[20] 
Panahi Y, Khalili N, Sahebi E, et al. Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial. Inflammopharmacology  2017; 25(1): 25-31.
[http://dx.doi.org/10.1007/s10787-016-0301-4] [PMID: 27928704] 
[21] 
Yen CH, Chu YJ, Lee BJ, Lin YC, Lin PT. Effect of liquid ubiquinol supplementation on glucose, lipids and antioxidant capacity in type 2 diabetes patients: a double-blind, randomised, placebo-controlled trial. Br J Nutr  2018; 120(1): 57-63.
[http://dx.doi.org/10.1017/S0007114518001241] [PMID: 29936921] 
[22] 
Czernichow S, Couthouis A, Bertrais S, et al. Antioxidant supplementation does not affect fasting plasma glucose in the Supplementation with Antioxidant Vitamins and Minerals (SU.VI.MAX) study in France: association with dietary intake and plasma concentrations. Am J Clin Nutr  2006; 84(2): 395-9.
[PMID: 16895889] 
[23] 
Volf I, Ignat I, Neamtu M, Popa VI. Thermal stability, antioxidant activity, and photo-oxidation of natural polyphenols. Chem Pap  2014; 68(1): 121-9.
[http://dx.doi.org/10.2478/s11696-013-0417-6] 
[24] 
Khan I, Saeed K, Khan I. Nanoparticles: Properties, applications and toxicities. Arab J Chem  2019; 12: 908-31.
[http://dx.doi.org/10.1016/j.arabjc.2017.05.011] 
[25] 
Ghaznavi H, Najafi R, Mehrzadi S, et al. Neuro-protective effects of cerium and yttrium oxide nanoparticles on high glucose-induced oxidative stress and apoptosis in undifferentiated PC12 cells. Neurol Res  2015; 37(7): 624-32.
[http://dx.doi.org/10.1179/1743132815Y.0000000037] [PMID: 25786672] 
[26] 
Hosseini A, Baeeri M, Rahimifard M, et al. Antiapoptotic effects of cerium oxide and yttrium oxide nanoparticles in isolated rat pancreatic islets. Hum Exp Toxicol  2013; 32(5): 544-53.
[http://dx.doi.org/10.1177/0960327112468175] [PMID: 23696423] 
[27] 
Khaksar MR, Rahimifard M, Baeeri M, et al. Protective effects of cerium oxide and yttrium oxide nanoparticles on reduction of oxidative stress induced by sub-acute exposure to diazinon in the rat pancreas. J Trace Elem Med Biol  2017; 41: 79-90.
[http://dx.doi.org/10.1016/j.jtemb.2017.02.013] [PMID: 28347467] 
[28] 
Zhang F, Wang Z, Wang S, et al. Physicochemical properties and ecotoxicological effects of yttrium oxide nanoparticles in aquatic media: Role of low molecular weight natural organic acids. Environ Pollut  2016; 212: 113-20.
[http://dx.doi.org/10.1016/j.envpol.2016.01.054] [PMID: 26840524] 
[29] 
Hosseini A, Sharifi AM, Abdollahi M, et al. Cerium and yttrium oxide nanoparticles against lead-induced oxidative stress and apoptosis in rat hippocampus. Biol Trace Elem Res  2015; 164(1): 80-9.
[http://dx.doi.org/10.1007/s12011-014-0197-z] [PMID: 25516117] 
[30] 
Zako T, Yoshimoto M, Hyodo H, et al. Cancer-targeted near infrared imaging using rare earth ion-doped ceramic nanoparticles. Biomater Sci  2015; 3(1): 59-64.
[http://dx.doi.org/10.1039/C4BM00232F] [PMID: 26214189] 
[31] 
Ma ZY, Dosev D, Nichkova M, Gee SJ, Hammock BD, Kennedy IM. Synthesis and bio-functionalization of multifunctional magnetic Fe(3)O(4)@Y(2)O(3):Eu nanocomposites. J Mater Chem  2009; 19(27): 4695-700.
[http://dx.doi.org/10.1039/b901427f] [PMID: 20357905] 
[32] 
Mitra RN, Merwin MJ, Han Z, Conley SM, Al-Ubaidi MR, Naash MI. Yttrium oxide nanoparticles prevent photoreceptor death in a light-damage model of retinal degeneration. Free Radic Biol Med  2014; 75: 140-8.
[http://dx.doi.org/10.1016/j.freeradbiomed.2014.07.013] [PMID: 25066531] 
[33] 
Schubert D, Dargusch R, Raitano J, Chan SW. Cerium and yttrium oxide nanoparticles are neuroprotective. Biochem Biophys Res Commun  2006; 342(1): 86-91.
[http://dx.doi.org/10.1016/j.bbrc.2006.01.129] [PMID: 16480682] 
[34] 
Chen J, Stimpson SE, Fernandez-Bueno GA, Mathews CE. Mitochondrial reactive oxygen species and type 1 diabetes. Antioxid Redox Signal  2018; 29(14): 1361-72.
[http://dx.doi.org/10.1089/ars.2017.7346] [PMID: 29295631] 
[35] 
Previte DM, Piganelli JD. Reactive oxygen species and their implications on CD4(+) T cells in type 1 diabetes. Antioxid Redox Signal  2018; 29(14): 1399-414.
[http://dx.doi.org/10.1089/ars.2017.7357] [PMID: 28990401] 
[36] 
Noble JA, Erlich HA. Genetics of type 1 diabetes. Cold Spring Harb Perspect Med  2012; 2(1): a007732.
[http://dx.doi.org/10.1101/cshperspect.a007732] [PMID: 22315720] 
[37] 
Khurana A, Anchi P, Allawadhi P, et al. Yttrium oxide nanoparticles reduce the severity of acute pancreatitis caused by cerulein hyperstimulation. Nanomedicine (Lond)  2019; 18: 54-65.
[http://dx.doi.org/10.1016/j.nano.2019.02.018] [PMID: 30851439] 
[38] 
Song X, Shang P, Sun Z, et al. Therapeutic effect of yttrium oxide nanoparticles for the treatment of fulminant hepatic failure. Nanomedicine (Lond)  2019; 14(19): 2519-33.
[http://dx.doi.org/10.2217/nnm-2019-0154] [PMID: 31317822] 
[39] 
Ayala A, Muñoz MF, Argüelles S. Lipid peroxidation: production, metabolism, and signaling mechanisms of malondialdehyde and 4-hydroxy-2-nonenal. Oxid Med Cell Longev  2014; 2014360438
[http://dx.doi.org/10.1155/2014/360438] [PMID: 24999379] 
[40] 
Davì G, Falco A, Patrono C. Lipid peroxidation in diabetes mellitus. Antiox Red Sign  2005; 7(1-2): 256-68.
[http://dx.doi.org/10.1089/ars.2005.7.256] [PMID: 15650413] 
[41] 
Mishra S, Mishra BB. Study of lipid peroxidation, nitric oxide end product, and trace element status in type 2 diabetes mellitus with and without complications. Int J Appl Basic Med Res  2017; 7(2): 88-93.
[http://dx.doi.org/10.4103/2229-516X.205813] [PMID: 28584737] 
[42] 
Malik A, Morya RK, Bhadada SK, Rana S. Type 1 diabetes mellitus: Complex interplay of oxidative stress, cytokines, gastrointestinal motility and small intestinal bacterial overgrowth. Eur J Clin Invest  2018; 48(11): e13021.
[http://dx.doi.org/10.1111/eci.13021] [PMID: 30155878] 
[43] 
Murunga AN, Miruka DO, Driver C, Nkomo FS, Cobongela SZ, Owira PM. Grapefruit derived flavonoid naringin improves ketoacidosis and lipid peroxidation in type 1 diabetes rat model. PLoS One  2016; 11(4): e0153241.
[http://dx.doi.org/10.1371/journal.pone.0153241] [PMID: 27073901] 
[44] 
Sheweita SA, Mashaly S, Newairy AA, Abdou HM, Eweda SM. Changes in oxidative stress and antioxidant enzyme activities in streptozotocin-induced diabetes mellitus in rats: role of Alhagi maurorum extracts. Oxid Med Cell Longev  2016; 20165264064
[http://dx.doi.org/10.1155/2016/5264064] [PMID: 26885249] 
[45] 
Ren B, Qin W, Wu F, et al. Apigenin and naringenin regulate glucose and lipid metabolism, and ameliorate vascular dysfunction in type 2 diabetic rats. Eur J Pharmacol  2016; 773: 13-23.
[http://dx.doi.org/10.1016/j.ejphar.2016.01.002] [PMID: 26801071] 
[46] 
Ahmadvand H. Amelioration of altered antioxidant enzyme activity by Satureja khuzistanica essential oil in alloxan-induced diabetic rats. Chin J Nat Med  2014; 12(9): 672-6.
[http://dx.doi.org/10.1016/S1875-5364(14)60102-3] [PMID: 25263978] 
[47] 
Yao Y, Zhao X, Xin J, Wu Y, Li H. Coumarins improved type 2 diabetes induced by high-fat diet and streptozotocin in mice via antioxidation. Can J Physiol Pharmacol  2018; 96(8): 765-71.
[http://dx.doi.org/10.1139/cjpp-2017-0612] [PMID: 29641229] 
[48] 
Gawlik K, Naskalski JW, Fedak D, et al. Markers of antioxidant defense in patients with type 2 diabetes. Oxid Med Cell Longev  2016; 20162352361
[http://dx.doi.org/10.1155/2016/2352361] [PMID: 26640613] 
[49] 
Hussain T, Tan B, Yin Y, Blachier F, Tossou MC, Rahu N. Oxidative stress and inflammation: What polyphenols can do for us? Oxid Med Cell Longev  2016; 20167432797
[http://dx.doi.org/10.1155/2016/7432797] [PMID: 27738491] 
[50] 
Tang KS. The cellular and molecular processes associated with scopolamine-induced memory deficit: A model of Alzheimer’s biomarkers. Life Sci  2019; 233116695
[http://dx.doi.org/10.1016/j.lfs.2019.116695] [PMID: 31351082] 
[51] 
Lontchi-Yimagou E, Sobngwi E, Matsha TE, Kengne AP. Diabetes mellitus and inflammation. Curr Diab Rep  2013; 13(3): 435-44.
[http://dx.doi.org/10.1007/s11892-013-0375-y] [PMID: 23494755] 
[52] 
Mussbacher M, Salzmann M, Brostjan C, et al. Cell type-specific roles of NF-kappaB linking inflammation and thrombosis. Front Immunol  2019; 10: 85.
[http://dx.doi.org/10.3389/fimmu.2019.00085] [PMID: 30778349] 
[53] 
Meyerovich K, Ortis F, Cardozo AK. The non-canonical NF-κB pathway and its contribution to β-cell failure in diabetes. J Mol Endocrinol  2018; 61(2): F1-6.
[http://dx.doi.org/10.1530/JME-16-0183] [PMID: 29728424] 
[54] 
Liu T, Zhang L, Joo D, Sun SC. NF-κB signaling in inflammation. Signal Transduct Target Ther  2017; 2: 17023.
[http://dx.doi.org/10.1038/sigtrans.2017.23] [PMID: 29158945] 
[55] 
Ganesh Yerra V, Negi G, Sharma SS, Kumar A. Potential therapeutic effects of the simultaneous targeting of the Nrf2 and NF-κB pathways in diabetic neuropathy. Redox Biol  2013; 1: 394-7.
[http://dx.doi.org/10.1016/j.redox.2013.07.005] [PMID: 24024177] 
[56] 
David JA, Rifkin WJ, Rabbani PS, Ceradini DJ. The Nrf2/Keap1/ARE pathway and oxidative stress as a therapeutic target in type II diabetes mellitus. J Diabetes Res  2017; 20174826724
[http://dx.doi.org/10.1155/2017/4826724] [PMID: 28913364] 
[57] 
Matzinger M, Fischhuber K, Heiss EH. Activation of Nrf2 signaling by natural products-can it alleviate diabetes? Biotechnol Adv  2018; 36(6): 1738-67.
[http://dx.doi.org/10.1016/j.biotechadv.2017.12.015] [PMID: 29289692] 
[58] 
Liu X, Chen K, Zhu L, et al. Soyasaponin Ab protects against oxidative stress in HepG2 cells via Nrf2/HO-1/NQO1 signaling pathways. J Funct Foods  2018; 45: 110-7.
[http://dx.doi.org/10.1016/j.jff.2018.03.037] 
[59] 
Tan BL, Norhaizan ME, Liew WP, Sulaiman Rahman H. Antioxidant and oxidative stress: a mutual interplay in age-related diseases. Front Pharmacol  2018; 9: 1162.
[http://dx.doi.org/10.3389/fphar.2018.01162] [PMID: 30405405] 
[60] 
Kawahara K, Hohjoh H, Inazumi T, Tsuchiya S, Sugimoto Y. Prostaglandin E2-induced inflammation: Relevance of prostaglandin E receptors. Biochim Biophys Acta  2015; 1851(4): 414-21.
[http://dx.doi.org/10.1016/j.bbalip.2014.07.008] [PMID: 25038274] 
[61] 
Bapna M, Chauhan LS. The ambidextrous cyclooxygenase: an enduring target. Inflamm Allergy Drug Targets  2015; 13(6): 387-92.
[http://dx.doi.org/10.2174/1871528114666150401105545] [PMID: 25827631] 
[62] 
Anuradha R, Saraswati M, Kumar KG, Rani SH. Apoptosis of beta cells in diabetes mellitus. DNA Cell Biol  2014; 33(11): 743-8.
[http://dx.doi.org/10.1089/dna.2014.2352] [PMID: 25093391] 
[63] 
Tomita T. Apoptosis in pancreatic β-islet cells in Type 2 diabetes. Bosn J Basic Med Sci  2016; 16(3): 162-79.
[http://dx.doi.org/10.17305/bjbms.2016.919] [PMID: 27209071] 
[64] 
Shalini S, Dorstyn L, Dawar S, Kumar S. Old, new and emerging functions of caspases. Cell Death Differ  2015; 22(4): 526-39.
[http://dx.doi.org/10.1038/cdd.2014.216] [PMID: 25526085] 
[65] 
Gojova A, Guo B, Kota RS, Rutledge JC, Kennedy IM, Barakat AI. Induction of inflammation in vascular endothelial cells by metal oxide nanoparticles: effect of particle composition. Environ Health Perspect  2007; 115(3): 403-9.
[http://dx.doi.org/10.1289/ehp.8497] [PMID: 17431490] 
[66] 
Selvaraj V, Bodapati S, Murray E, et al. Cytotoxicity and genotoxicity caused by yttrium oxide nanoparticles in HEK293 cells. Int J Nanomedicine  2014; 9: 1379-91.
[http://dx.doi.org/10.2147/IJN.S52625] [PMID: 24648735] 
[67] 
Moriyama A, Takahashi U, Mizuno Y, Takahashi J, Horie M, Iwahashi H. The truth of toxicity caused by yttrium oxide nanoparticles to yeast cells. J Nanosci Nanotechnol  2019; 19(9): 5418-25.
[http://dx.doi.org/10.1166/jnn.2019.16544] [PMID: 30961691] 
[68] 
Castro-Bugallo A, González-Fernández Á, Guisande C, Barreiro A. Comparative responses to metal oxide nanoparticles in marine phytoplankton. Arch Environ Contam Toxicol  2014; 67(4): 483-93.
[http://dx.doi.org/10.1007/s00244-014-0044-4] [PMID: 24908584] 
[69] 
Panyala A, Chinde S, Kumari SI, et al. Comparative study of toxicological assessment of yttrium oxide nano- and microparticles in Wistar rats after 28 days of repeated oral administration. Mutagenesis  2019; 34(2): 181-201.
[http://dx.doi.org/10.1093/mutage/gey044] [PMID: 30753658] 
[70] 
Panyala A, Chinde S, Kumari SI, Grover P. Assessment of genotoxicity and biodistribution of nano- and micron-sized yttrium oxide in rats after acute oral treatment. J Appl Toxicol  2017; 37(12): 1379-95.
[http://dx.doi.org/10.1002/jat.3505] [PMID: 28685832] 
[71] 
Parhofer KG. Interaction between glucose and lipid metabolism: More than diabetic dyslipidemia. Diabetes Metab J  2015; 39(5): 353-62.
[http://dx.doi.org/10.4093/dmj.2015.39.5.353] [PMID: 26566492] 
[72] 
Akbari-Fakhrabadi M, Heshmati J, Sepidarkish M, Shidfar F. Effect of sumac (Rhus Coriaria) on blood lipids: A systematic review and meta-analysis. Complement Ther Med  2018; 40: 8-12.
[http://dx.doi.org/10.1016/j.ctim.2018.07.001] [PMID: 30219474] 
[73] 
Darvish Damavandi R, Mousavi SN, Shidfar F, et al. Effects of daily consumption of cashews on oxidative stress and atherogenic indices in patients with type 2 diabetes: A randomized, controlled-feeding trial. Int J Endocrinol Metab  2019; 17(1): e70744.
[http://dx.doi.org/10.5812/ijem.70744] [PMID: 30881468] 
[74] 
Heshmati J, Morvaridzadeh M, Sepidarkish M, et al. Effects of Melissa officinalis (Lemon Balm) on cardio-metabolic outcomes: A systematic review and meta-analysis. Phytother Res 2020. [Online ahead of print].
[http://dx.doi.org/10.1002/ptr.6744] [PMID: 32614129] 
[75] 
Ravanan P, Srikumar IF, Talwar P. Autophagy: The spotlight for cellular stress responses. Life Sci  2017; 188: 53-67.
[http://dx.doi.org/10.1016/j.lfs.2017.08.029] [PMID: 28866100] 
[76] 
Volpe CMO, Villar-Delfino PH, Dos Anjos PMF, Nogueira-Machado JA. Cellular death, reactive oxygen species (ROS) and diabetic complications. Cell Death Dis  2018; 9(2): 119.
[http://dx.doi.org/10.1038/s41419-017-0135-z] [PMID: 29371661] 
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DOI https://dx.doi.org/10.2174/1573399816999201012201111	Print ISSN 1573-3998
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Current Diabetes Reviews

Antioxidant and Anti-inflammatory Properties of Yttrium Oxide Nanoparticles: New Insights into Alleviating Diabetes

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