The Synthesis and Chemistry of 2-Imino-2H-Chromene-3-Carbo(Thio) Amides

Title:The Synthesis and Chemistry of 2-Imino-2H-Chromene-3-Carbo(Thio) Amides

Volume: 18 Issue: 6

Author(s): Tarik E. Ali*, Hafez M. El-Shaaer, Somaia M. Abdel-Kariem, Mai S. A. Hussien, Ibrahim S. Yahia and Heba Y. Zahran

Affiliation:

• Department of Chemistry, Faculty of Science, King Khalid University, Abha,Saudi Arabia

Keywords: Chromene, imino, amide, synthesis, reactivity, cyclization, nucleophiles, electrophiles.

Abstract: 2-Imino-2H-chromene-3-carbo(thio)amides are considered versatile compounds because of their significance as building blocks in synthetic chemistry. In this review, we display all the available synthetic methods for 2-imino-2H-chromene-3-carbo(thio)amides as well as their reactions towards the different reagents. The presence of the imino and amide groups in these compounds makes C-4 the only reactive site of the pyran ring with a unique reactivity that could react with different reagents. The appropriate applications for the synthesis of condensed chromene derivatives and their relevancy are reported. The reactions of 2-imino-2H-chromene-3- carbo(thio)amides were divided into several categories depending on the used reagents in the reactions.

Cite this article as:

Ali E. Tarik *, El-Shaaer M. Hafez , Abdel-Kariem M. Somaia , Hussien S. A. Mai , Yahia S. Ibrahim and Zahran Y. Heba , The Synthesis and Chemistry of 2-Imino-2H-Chromene-3-Carbo(Thio) Amides, Mini-Reviews in Organic Chemistry 2021; 18 (6) . https://dx.doi.org/10.2174/1570193X17999201012182420