A Five-gene Signature for Predicting the Prognosis of Colorectal Cancer

(E-pub Ahead of Print)

Author(s): Junfeng Hong, Xiangwu Lin, Xinyu Hu, Xiaolong Wu, Wenzheng Fang*

Journal Name: Current Gene Therapy

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Abstract:

Background: Colorectal cancer (CRC) is a kind of tumor with high incidence and its treatment situation is still very severe despite of the constant renewal and development of treatment methods.

Objective: To assist the prognosis, monitoring and survival of CRC patients with a model.

Methods: In this study, we established a new prognostic model for CRC. Four groups of CRC data were accessed from GEO database, and then differential analysis (logFoldChange>1, adjustP<0.05) was carried out by using limma package along with the RobustRankAggreg package used to identify the overlapping differentially expressed genes (DEGs). Univariate and multivariate Cox regression analyses were performed on the DEGs to screen the genes related to patient’s prognosis, and a five-gene prognostic prediction model (including RPX, CXCL13, MMP10, FABP4 and CLDN23) was constructed. Then, we further plotted ROC curves to evaluate the predictive performance of the five-gene prognostic signature in the TCGA data sets (the AUC values of 1, 3, 5-year survival were 0.68, 0.632, 0.675, respectively) and an external independent data set GSE2962 (the AUC values of 1, 3, 5-year survival were 0.689, 0.702, 0.631, respectively).

Results: The results showed that the model could effectively predict the prognosis of CRC patients, which provides a robust predictive model for the prognosis of CRC patients.

Conclusion: The model could effectively predict the prognosis of CRC patients, which provides a robust predictive model for the prognosis of CRC patients.

Keywords: Prognosis, signature, CRC, predictive, CLDN23, FABP4, MMP10, CXCL13.

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(E-pub Ahead of Print)
DOI: 10.2174/1566523220666201012151803
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