Background: A number of synthetic scaffolds, along with natural products, have been
identified as potent antioxidants. The present study deals with the evaluation of varyingly substituted,
medicinally distinct class of compounds “chalcones and bis-chalcones” for their antioxidant potential.
Methods: In vitro radical scavenging activities were performed on a series of synthetic chalcones 1-
13 and bis-chalcones 14-18.
Results: All molecules 1-18 revealed a pronounced 2-diphenyl-1-picrylhydrazyl (DPPH) and 2,2ʹ-
azino-bis(3-ethylbenzothiazoline-6-sulphonic acid) (ABTS) radicals scavenging potential in the
ranges of IC50s = 0.58 ± 0.14 - 1.72 ± 0.03 and 0.49 ± 0.3 - 1.48 ± 0.06 μM, respectively. Ascorbic
acid (IC50s = 0.5 ± 0.1 and 0.46 ± 0.17 μM for DPPH and ABTS, respectively) was used as a standard
Conclusion: Structure-activity relationship (SAR) revealed an active participation of various
groups, including -SMe and -OMe in scavenging activity.