Recent Update on the Anti-infective Potential of β-carboline Analogs

Title:Recent Update on the Anti-infective Potential of β-carboline Analogs

Volume: 21 Issue: 4

Author(s): Faheem, Banoth Karan Kumar, Kondapalli Venkata Gowri Chandra Sekhar, Selvaraj Kunjiappan, Joazaizulfazli Jamalis, Rafael Balaña-Fouce and Murugesan Sankaranarayanan*

Affiliation:

• Medicinal Chemistry Research Laboratory, Department of Pharmacy, Birla Institute of Technology and Science Pilani, Pilani Campus, Vidya Vihar, Pilani-333031, Rajasthan,India

Keywords: β-Carboline, PYRIDO indole, antibacterial, antifungal, antiviral, antiprotozoal.

Abstract: β-Carboline, a naturally occurring indole alkaloid, holds a momentous spot in the field of medicinal chemistry due to its myriad of pharmacological actions like anticancer, antiviral, antibacterial, antifungal, antileishmanial, antimalarial, neuropharmacological, anti-inflammatory and antithrombotic among others. β-Carbolines exhibit their pharmacological activity via diverse mechanisms. This review provides a recent update (2015-2020) on the anti-infective potential of natural and synthetic β-carboline analogs focusing on its antibacterial, antifungal, antiviral, antimalarial, antileishmanial and antitrypanosomal properties. In cases where enough details are available, a note on its mechanism of action is also added.

Cite this article as:

Faheem , Kumar Karan Banoth , Sekhar Gowri Chandra Kondapalli Venkata , Kunjiappan Selvaraj , Jamalis Joazaizulfazli, Balaña-Fouce Rafael and Sankaranarayanan Murugesan *, Recent Update on the Anti-infective Potential of β-carboline Analogs, Mini-Reviews in Medicinal Chemistry 2021; 21 (4) . https://dx.doi.org/10.2174/1389557520666201001130114