Purpose: A new human coronavirus (SARS-CoV-2), triggering pneumonia is termed as Coronavirus Disease-19
(COVID-19). There is an alarming situation now as this new virus is spreading around the world. At present, there are no
specific treatments for COVID-19. Nigella sativa is known as Prophetic Medicine as its use has been mentioned in Prophetic
Hadith, as natural remedy for all the diseases except death. Seeds and oils of N. sativa have a long history of folklore usage
in various system of medicine such as Unani & Tibb, Ayurveda & Siddha in the treatment of different diseases and ailments.
The aim of this research is to provide potential inhibitor of SARS-CoV-2 Mpro
Method: The Molecular docking tool was used to optimize the binding affinities of chemical constituents of N. sativa with
Results: Many constituents from N. Sativa have shown better binding affinity than reported drugs with SARS-CoV-2 Mpro
i.e. the alpha-hederin, Stigmasterol glucoside, Nigellidine-4-O-sulfite, Nigellidine, Sterol-3-β-D-glucoside, Dithymoquinone, beta-sitosterol have binding affinities (kcal/mol) -9, -8.1, -8, -7.7, -7.7, -7.4, -7.4, -6.9 and no. of hydrogen bonds
formed are 06, 04, 03, 03, 03, 00 and 01 respectively.
Conclusion: There is rationale and pre-clinical evidence of effectiveness of N. Sativa that it may be helpful for the treatment
of COVID-19 and can serve as potential natural candidate. However, more studies should be conducted to collect high
quality data and scientific evidences of N. Sativa to use it against COVID-19 clinically.