Reactions in water have demonstrated numerous surprising results. The effects
of water in these reactions may include significant physical and chemical interactions with
the substrates and catalysts through polar effects and hydrogen bonding ability. In some
instances, water is also able to interact with the intermediates of reactions and possibly
with the transition states of chemical processes. Organic synthesis in water encourages the
researchers to follow the principles of green chemistry. Among heterocyclic compounds,
quinoline scaffold has become an important motif for the development of new
drugs. They are widely found in pharmaceuticals as well as in agrochemical industry. Over
the last few decades, numerous reports have been documented to access quinoline derivatives
with structural diversity, either by new annulation or by ring functionalization. This review summarizes an
overview of the synthesis and functionalisation of quinoline scaffolds in an aqueous medium. This method may
encourage researchers to adopt green chemistry and to apply these environmentally safe methods in designing
important heterocyclic cores.
Keywords: Polar effects, hydrogen bonding, structural diversity, annulation, synthesis, agrochemical.
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