Asymmetric Organocatalyzed Warfarin Synthesis in Aqueous and Nonaqueous Media: A Discussion in the Era of COVID-19 Pandemic

(E-pub Ahead of Print)

Author(s): Anirban Mondal, Kartick C. Bhowmick*

Journal Name: Current Organocatalysis

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The recent widespread infection of COVID-19 in the entire world has created pandemic situation with a serious health challenge to the mankind. Numerous incidents of cardiovascular disease were found among COVID-19 patients with a significantly high morbidity rate. Medication with several anticoagulant or blood thinner drugs are being performed on COVID-19 patients with atrial fibrillation and cardiovascular ailments to minimize the incidence of death. Warfarin is widely used anticoagulant and cardiovascular drug prescribed as its sodium salt. S-Enantiomer is two to five times more active than R-enantiomer as anticoagulant. Synthesis of enantiomerically pure warfarin is thus a rational and extremely important task. Organocatalyzed synthetic strategies may be considered as important avenues to produce optically pure warfarin in comparison to biocatalysis and chiral metal complex catalysis. Herein, a comprehensive review on the asymmetric organocatalyzed synthesis of warfarin catalysed by diamine based organocatalysts, amino acid based organocatalysts, quinine based organocatalysts and proline derived organocatalysts in both aqueous and non-aqueous media has been discussed.

Keywords: COVID-19, Cardiovascular diseases, Anticoagulant, Organocatalysis, Warfarin synthesis, Michael reaction, Aqueous media, Non-aqueous media.

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(E-pub Ahead of Print)
DOI: 10.2174/2213337207999200909115215
Price: $95