The recent widespread infection of COVID-19 in the entire world has created pandemic situation with a serious
health challenge to the mankind. Numerous incidents of cardiovascular disease were found among COVID-19 patients
with a significantly high morbidity rate. Medication with several anticoagulant or blood thinner drugs are being performed
on COVID-19 patients with atrial fibrillation and cardiovascular ailments to minimize the incidence of death. Warfarin is
widely used anticoagulant and cardiovascular drug prescribed as its sodium salt. S-Enantiomer is two to five times more
active than R-enantiomer as anticoagulant. Synthesis of enantiomerically pure warfarin is thus a rational and extremely
important task. Organocatalyzed synthetic strategies may be considered as important avenues to produce optically pure
warfarin in comparison to biocatalysis and chiral metal complex catalysis. Herein, a comprehensive review on the
asymmetric organocatalyzed synthesis of warfarin catalysed by diamine based organocatalysts, amino acid based
organocatalysts, quinine based organocatalysts and proline derived organocatalysts in both aqueous and non-aqueous
media has been discussed.
Keywords: COVID-19, Cardiovascular diseases, Anticoagulant, Organocatalysis, Warfarin synthesis, Michael reaction,
Aqueous media, Non-aqueous media.
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