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Current Organic Chemistry

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ISSN (Online): 1875-5348

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Review Article

Recent Progress in the Synthesis of Benzo[b]thiophene

Author(s): Dau Xuan Duc*

Volume 24, Issue 19, 2020

Page: [2256 - 2271] Pages: 16

DOI: 10.2174/1385272824999200820151545

Price: $65

Abstract

Benzo[b]thiophenes are aromatic heterocyclic compounds containing benzene and thiophene rings. This class of heterocycles is present in a large number of natural and non-natural compounds. Benzo[b]thiophene derivatives have a broad range of applications in medicinal chemistry such as antimicrobial, anticancer, antioxidant, anti-HIV and antiinflammatory activities. The use of benzo[b]thiophene derivatives in other fields has also been reported. Various benzo[b]thiophenes compounds have been employed as organic photoelectric materials, while several benzo[b]thiophenes have been used as organic semiconductors. Benzo[b]thiophenes have also been used as building blocks or intermediates for the synthesis of pharmaceutically important molecules.

Due to such a wide range of applicability, the synthesis of benzo[b]thiophene derivatives has attracted intensive research. Numerous mild and efficient approaches for the synthesis of benzo[b]thiophenes have been developed over the years. Different catalysts and substrates have been applied for benzo[b]thiophene synthesis. This review will focus on the studies in the construction of benzo[b]thiophene skeleton, which date back from 2012.

Keywords: Benzo[b]thiophene, cyclization, 2-alkynylanisoles, Sonogashira coupling, alkynes, thiophenols.

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