Title:Mesenchymal Stem Cells Mediated Drug Delivery in Tumor-Targeted Therapy
VOLUME: 17
Author(s):Mengying Xie, Lei Tao, Ziqi Zhang and Wei Wang*
Affiliation:Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, Nangjing Institute for Food and Drug Control, 199 Wenfang Road, Nangjing 211198,, Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198, Department of Pharmaceutics, China Pharmaceutical University, 639 Longmian Avenue, Nanjing 211198
Keywords:mesenchymal stem cells, tumor-targeted therapy, cell mediated drug delivery, exosomes, nanoparticles, gene therapy
Abstract:Mesenchymal stem cells (MSCs) possess unique properties that make them potential carriers for cancer therapy. MSCs have been documented to have low immunogenicity, positive safety in clinical trials, and the ability to selectively homing to inflammation and tumor sites. Thisreview aims to introduce tumor tropism mechanism and effects of MSCs on tumor cells, and give an overview of MSCs in delivering gene therapeutic agents, oncolytic viruses and chemotherapeutics, as well as the application of MSCs-derived exosomes in tumor-targeted therapy.
