Investigation of the Effect of Loratadine and Calcium Ions on Oxidoreductase Activity of Catalase Enzyme

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Author(s): Edhem Hasković, Safija Herenda*, Zehra Halilović, Snežana Unčanin, Denis Hasković, Ena Deljkić

Journal Name: Current Enzyme Inhibition

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Background: The Spectrophotometric method is one of the most suitable analytical techniques for testing the activity of enzymes under the influence of various factors. Methods: The effect of H1-antihistamines of loratadine and calcium ions on enzyme catalase under in vitro conditions was investigated in this paper.

Results and Discussion: It has been shown that loratadine isa partial inhibitor of catalase, but this effect is diminished in the presence of calcium ions. Calcium as well as other cations are important for many biological and cellular functions. The kidneys play a central role in the homeostasis of these ions. The activity of the catalase enzyme under the given conditions, the type of inhibition,and the kinetic parameters of the enzyme reaction were determined.

Conclusion: We concluded that loratadine is a partially competitive inhibitor.

Keywords: spectrophotometric method, catalase, loratadine, calcium ions, inhibitor, enzyme inhibition

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(E-pub Ahead of Print)
DOI: 10.2174/1573408016999200817173859
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