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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Research Article

Microwave-Assisted Regioselective Synthesis of Variously Functionalized [1,2,4]triazolo[3,4-b]quinazolin-5(1H)-ones

Author(s): Awad I. Said, Matti Haukka and Ferenc Fülöp*

Volume 24, Issue 16, 2020

Page: [1892 - 1896] Pages: 5

DOI: 10.2174/1385272824666200814134911

Price: $65

Abstract

[1,2,4]Triazolo[3,4-b]quinazolin-5(1H)-ones with varied functionalization patterns were synthesized in a regioselective manner by reacting 2-thioxo-2,3- dihydroquinazolin-4(1H)-one (2) with variously functionalized hydrazonoyl chlorides (3ah). Linear regioselectivity of the formed products was confirmed by X-ray measurements. Under microwave conditions, the reactions were completed in a few minutes without a change in the regioselectivity.

Keywords: Triazolo[3, 4-b]quinazoline, 2-thioxo-2, 3-dihydroquinazolin-4(1H)-one, hydrazonoyl chlorides, regioselectivity, microwaveassisted reaction, X-ray.

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