Background: Acetylation of protic nucleophiles is used to protect these functional groups. Most of the methods
described in the literature use solvents, one equivalent or more of toxic bases or expensive and toxic catalysts. Therefore,
new methodologies are still in demand, above all, greener and more economical procedures.
Objective: An eco-efficient method developed for acetylation of alcohols, phenols, thiols, amines and carbohydrates, using acetic anhydride and a catalytic amount of the environmentally benign and inexpensive FeCl3.6H2O under solvent
Methods: Acetylation of a variety of protic nucleophiles was performed using 0.2 mol % of FeCl3.6H2O as the catalyst,
and 1.2 equiv. as the acetylating agent at room temperature and under solvent free conditions.
Results: Our procedure appears to be highly efficient and promoted rapid and quantitative acetylation under simple and
minimum manipulation. Chromatography or recrystallization were generally not necessary for the purification of products.
Conclusion: This eco-friendly protocol appears to be potentially universally applicable in organic design to protect protic
nucleophiles and potentially scalable for industrial fields.