Generic placeholder image

Mini-Reviews in Medicinal Chemistry

Editor-in-Chief

ISSN (Print): 1389-5575
ISSN (Online): 1875-5607

Mini-Review Article

Focus on Phytochemical and Pharmacological Profile of Prunus lycioides (=Amygdalus lycioides)

Author(s): Valeria Cavalloro, Francesco Bracco, Simona Collina and Emanuela Martino*

Volume 20, Issue 20, 2020

Page: [2207 - 2214] Pages: 8

DOI: 10.2174/1389557520666200730153653

Price: $65

Abstract

Prunus lycioides (Spach) C.K. Schneid. (= Amygdalus lycioides Spach.), popularly recognized as “Badam Talkh kuhi”, is an endemic species of Iran. It is widely distributed in Central and West Asia, where it plays a role in preventing and controlling soil erosion. Although domestic species of Prunus genus are well known and widely used in food, pharmaceutical, and cosmetic industries, inadequate information about wild species is available so far. As far as Prunus lycioides, it is commonly used by native people in traditional medicine for treating diabetes, inflammatory diseases, and microbial infections. The wild almonds are traditionally exploited for oil extraction due to their antioxidant properties. This review summarizes advances in the studies regarding Prunus lycioides and its pharmacological properties. The aim of the review is to renew the interest in this promising plant, thus stimulating researchers to go further with the study for discovering new bioactive compounds.

Keywords: Prunus lycioides, Amygdalus lycioides, Unani, Ethnobotany, Nature-Aided Drug Discovery, Traditional medicine.

Graphical Abstract
[1]
Babael, H.; Sadeghpour, O.; Nahar, L.; Delazar, A.; Nazemiyeh, H.; Mansouri, M.R.; Poursaeid, N.; Asnaashari, S.; Moghadam, S.B.; Sarker, S.D. Antioxidant and Vasorelaxant Activities of Flavonoids from Amygdalus lycioides var. horrida. Turk. J. Biol., 2008, 32, 203-208.
[2]
Abdullah, M.K.; Hussain, M.K. Badam (Prunus amygdalus Bail.): A fruit with medicinal properties. Int. J. Herb. Med., 2017, 5, 114-117.
[3]
Amanzadeh, Y.; Hajimehdipoor, H.; Abedi, Z.; Khatamsaz, M. Chemical constituents of Amygdalus spp. oil from Iran. Res. J. Pharmacogn., 2016, 3, 29-33.
[4]
Isfahlan, A.J.; Mahmoodzadeh, A.; Hassanzadeh, A.; Heidari, R.; Jamei, R. Antioxidant and antiradical activities of phenolic extracts from Iranian almond (Prunus amygdalus L.) hulls and shells. TURKISH J. Biol., 2010, 34, 165-173.
[5]
Gaggeri, R.; Rossi, D.; Christodoulou, M.S.; Passarella, D.; Leoni, F.; Azzolina, O.; Collina, S. Chiral flavanones from Amygdalus lycioides Spach: Structural elucidation and identification of TNFalpha inhibitors by bioactivity-guided fractionation. Molecules, 2012, 17(2), 1665-1674.
[http://dx.doi.org/10.3390/molecules17021665] [PMID: 22318322]
[6]
Moezi, L.; Arshadi, S.S.; Motazedian, T.; Seradj, S.H.; Dehghani, F. Anti-diabetic effects of Amygdalus lycioides spach in streptozocin-induced diabetic rats. Iran. J. Pharm. Res., 2018, 17(1), 353-364.
[PMID: 29755566]
[7]
Tabatabai, S.M.; Amin, G.; Jalali, S.; Avatefi Hemat, M.; Afshari, F. Ethnopharmacology of Amygdalus lycioides spach var. horrida in east of esfahan in Iran. J. Med. Plants, 2018, 2, 38-49.
[8]
Potter, D.; Eriksson, T.; Evans, R.C.; Oh, S.; Smedmark, J.E.E.; Morgan, D.R.; Kerr, M.; Robertson, K.R.; Arsenault, M.; Dickinson, T.A.; Campbell, C.S. Phylogeny and classification of Rosaceae. Plant Syst. Evol., 2007, 266, 5-43.
[http://dx.doi.org/10.1007/s00606-007-0539-9]
[9]
Parsa, A. Medicinal plants and drugs of plant origin in Iran. IV. Qual. Plant. Mater. Veg., 1960, 7, 65-136.
[http://dx.doi.org/10.1007/BF01260413]
[10]
Choi, J.H.; Cha, D.S.; Jeon, H. Anti-inflammatory and anti-nociceptive properties of Prunus padus. J. Ethnopharmacol., 2012, 144(2), 379-386.
[http://dx.doi.org/10.1016/j.jep.2012.09.023] [PMID: 23010365]
[11]
Magiera, A.; Marchelak, A.; Michel, P.; Owczarek, A.; Olszewska, M.A. Lipophilic extracts from leaves, inflorescences and fruits of Prunus padus L. as potential sources of corosolic, ursolic and oleanolic acids with anti-inflammatory activity. Nat. Prod. Res., 2019, 1-6.
[http://dx.doi.org/10.1080/14786419.2019.1666385] [PMID: 31533493]
[12]
Baek, S.C.; Park, M.H.; Ryu, H.W.; Lee, J.P.; Kang, M.G.; Park, D.; Park, C.M.; Oh, S.R.; Kim, H. Rhamnocitrin isolated from Prunus padus var. seoulensis: A potent and selective reversible inhibitor of human monoamine oxidase A. Bioorg. Chem., 2019, 83, 317-325.
[http://dx.doi.org/10.1016/j.bioorg.2018.10.051] [PMID: 30396116]
[13]
Donno, D.; Mellano, M.G.; De Biaggi, M.; Riondato, I.; Rakotoniaina, E.N.; Beccaro, G.L. New findings in prunus padus l. fruits as a source of natural compounds: characterization of metabolite profiles and preliminary evaluation of antioxidant activity. Molecules, 2018, 23(4), 725.
[http://dx.doi.org/10.3390/molecules23040725] [PMID: 29565317]
[14]
Noh, D.; Joe, S.; Yang, H.; Han, D.; Kim, J.; Kim, D. Antimicrobial activity and safety test of natural extract including phellodendro namurense, eucommia ulmides oliv extracts. Korean Chem. Eng. Res., 2016, 54, 762-766.
[http://dx.doi.org/10.9713/kcer.2016.54.6.762]
[15]
Vakili, M.; Ahmadipour, S.; Rahmani, P. Concise review: Herbal remedies and herbal plants for constipation in children. Biomed. Res. Ther., 2018, 5, 2260-2267.
[http://dx.doi.org/10.15419/bmrat.v5i5.438]
[16]
Lee, H.H.; Ahn, J-H.; Kwon, A-R.; Lee, E.S.; Kwak, J-H.; Min, Y-H. Chemical composition and antimicrobial activity of the essential oil of apricot seed. Phytother. Res., 2014, 28(12), 1867-1872.
[http://dx.doi.org/10.1002/ptr.5219] [PMID: 25219371]
[17]
Komakech, R.; Kang, Y.; Lee, J-H.; Omujal, F. A Review of the potential of phytochemicals from Prunus africana (Hook f.) Kalkman stem bark for chemoprevention and chemotherapy of prostate cancer. Evid.-. Based Complement. Altern. Med., 2017, 2017, 1-10.
[18]
Mwitari, P.G.; Ayeka, P.A.; Ondicho, J.; Matu, E.N.; Bii, C.C. Antimicrobial activity and probable mechanisms of action of medicinal plants of Kenya: Withania somnifera, Warbugia ugandensis, Prunus africana and Plectrunthus barbatus. PLoS One, 2013, 8(6)e65619
[http://dx.doi.org/10.1371/journal.pone.0065619] [PMID: 23785437]
[19]
Arora, D.S.; Mahajan, H. Major phytoconstituents of Prunus cerasoides responsible for antimicrobial and antibiofilm potential against some reference strains of pathogenic bacteria and clinical isolates of MRSA. Appl. Biochem. Biotechnol., 2019, 188(4), 1185-1204.
[http://dx.doi.org/10.1007/s12010-019-02985-4] [PMID: 30854606]
[20]
Sharma, A.; Joshi, R.; Kumar, S.; Sharma, R. Rajneesh; Padwad, Y.; Gupta, M. Prunus cerasoides fruit extract ameliorates inflammatory stress by modulation of iNOS pathway and Th1/Th2 immune homeostasis in activated murine macrophages and lymphocytes. Inflammopharmacology, 2018, 26(6), 1483-1495.
[http://dx.doi.org/10.1007/s10787-018-0448-2] [PMID: 29429000]
[21]
Malsawmtluangi, C.; Thanzami, K.; Lalhlenmawia, H.; Selvan, V.; Palanisamy, S.; Kandasamy, R.; Pachuau, L. Physicochemical characteristics and antioxidant activity of Prunus cerasoides D. Don gum exudates. Int. J. Biol. Macromol., 2014, 69, 192-199.
[http://dx.doi.org/10.1016/j.ijbiomac.2014.05.050] [PMID: 24875319]
[22]
Condello, M.; Pellegrini, E.; Spugnini, E.P.; Baldi, A.; Amadio, B.; Vincenzi, B.; Occhionero, G.; Delfine, S.; Mastrodonato, F.; Meschini, S. Anticancer activity of “Trigno M”, extract of Prunus spinosa drupes, against in vitro 3D and in vivo colon cancer models. Biomed. Pharmacother., 2019, 118109281
[http://dx.doi.org/10.1016/j.biopha.2019.109281] [PMID: 31377469]
[23]
Stanković, M.I.; Savić, V.L.; Živković, J.V.; Tadić, V.M.; Arsić, I.A. Tyrosinase inhibitory and antioxidant activity of wild Prunus spinosa L. Fruit extracts as natural source of bioactive compounds. Not. Bot. Horti Agrobot. Cluj-Napoca, 2019, 47(3), 651-657.
[http://dx.doi.org/10.15835/nbha47311425]
[24]
Marchelak, A.; Owczarek, A.; Rutkowska, M.; Michel, P.; Kolodziejczyk-Czepas, J.; Nowak, P.; Olszewska, M.A. New insights into antioxidant activity of Prunus spinosa flowers: Extracts, model polyphenols and their phenolic metabolites in plasma towards multiple in vivo-relevant oxidants. Phytochem. Lett., 2019, 30, 288-295.
[http://dx.doi.org/10.1016/j.phytol.2019.02.011]
[25]
Gegiu, G.; Branza, A-D.; Bucur, L.; Grigorian, M.; Tache, T.; Badea, V. Contributions to the antimicrobial and antifungal study of the aqueous extract of Prunus spinosa L. Farmacia, 2015, 63, 275-279.
[26]
Dhingra, N.; Kar, A.; Sharma, R. Inhibition of aromatase and cell proliferation of breast cancer and human placenta choriocarcinoma by Prunus persica extracts. Indian J. Pharm. Sci., 2018, 80.
[http://dx.doi.org/10.4172/pharmaceutical-sciences.1000437]
[27]
Lee, C.K.; Park, K-K.; Hwang, J-K.; Lee, S.K.; Chung, W-Y. The pericarp extract of Prunus persica attenuates chemotherapy-induced acute nephrotoxicity and hepatotoxicity in mice. J. Med. Food, 2008, 11(2), 302-306.
[http://dx.doi.org/10.1089/jmf.2007.545] [PMID: 18598173]
[28]
Nakagawa, T.; Allam, A.E.; Ohnuki, K.; Shimizu, K. Biological activities of extracts from different parts of two cultivars of Prunus persica ‘Akatsuki’ and ‘Fastigiata.’. Nat. Prod. Commun., 2018, 13.
[29]
Qureshi, M.N.; Numonov, S.; Aisa, H.A. Total polyphenolic compounds, total flavonoids, GC-MS analysis of volatile constituents, evaluation of antioxidant and antimicrobial activities of Prunus dulcis nuts. Pak. J. Pharm. Sci., 2019, 32(4), 1461-1466.
[PMID: 31608863]
[30]
Lakhdari, A.; Merazi, Z.; Hanitet Nour, E.H.; Drir, F.Z. Ethnobotanical study of medicinal plants used for the treatment of Diabetes mellitus in Sidi Bel Abbes region (North-west Algeria) Boletín Latinoam. Y del caribe plantas Med. Y AROMÁTICAS 2019, 18, 392-410.
[31]
Gorji, N.; Moeini, R.; Memariani, Z. Almond, hazelnut and walnut, three nuts for neuroprotection in Alzheimer’s disease: A neuropharmacological review of their bioactive constituents. Pharmacol. Res., 2018, 129, 115-127.
[http://dx.doi.org/10.1016/j.phrs.2017.12.003] [PMID: 29208493]
[32]
Alisoltani, A.; Ebrahimi, S.; Azarian, S.; Hematyar, M.; Shiran, B.; Jahanbazi, H.; Fallahi, H.; Mousavi-Fard, S.; Rafiei, F. Parallel consideration of SSRs and differentially expressed genes under abiotic stress for targeted development of functional markers in almond and related Prunus species. Sci. Hortic. (Amsterdam), 2016, 198, 462-472.
[http://dx.doi.org/10.1016/j.scienta.2015.10.020]
[33]
Shi, S.; Li, J.; Sun, J.; Yu, J.; Zhou, S. Phylogeny and classification of Prunus sensu lato (Rosaceae). J. Integr. Plant Biol., 2013, 55(11), 1069-1079.
[http://dx.doi.org/10.1111/jipb.12095] [PMID: 23945216]
[34]
Karatas, S.; Çetin, A.; Atamov, V.; Aslan, M. Morphologic, ecologic and taxonomic studies on Amygdalus l. species in sanliurfa, Turkey. Acta Hortic., 2011, 507-514.
[http://dx.doi.org/10.17660/ActaHortic.2011.912.77]
[35]
Catalogue of Life: 2019 Annual Checklist.. 2019.
[36]
Browicz, K.; Zohary, D. The genus Amygdalus L. (Rosaceae): Species relationships, distribution and evolution under domestication. Genet. Resour. Crop Evol., 1996, 43, 229-247.
[http://dx.doi.org/10.1007/BF00123275]
[37]
Gaggeri, R.; Rossi, D.; Hajikarimian, N.; Martino, E.; Bracco, F.; Grisoli, P.; Dacarro, C.; Leoni, F.; Mascheroni, G.; Collina, S.; Azzolina, O. Preliminary study on TNFalfa-Blocker activity of amygdalus lycioides spach extracts. Open Nat. Prod. J., 2010, 3, 20-25.
[http://dx.doi.org/10.2174/1874848101003010020]
[38]
Agrawal, P.K. Carbon-13 NMR of flavonoids. Elsevier Science, 1st ed; , 1989.
[39]
Mabry, T.J.; Markham, K.R.; Thomas, M.B. The Systematic Identification of Flavonoids; Springer Berlin Heidelberg: Berlin, Heidelberg, 1970.
[http://dx.doi.org/10.1007/978-3-642-88458-0]
[40]
Rouhi, V.; Samson, R.; Lemeur, R.; Van Damme, P. Photosynthetic gas exchange characteristics in three different almond species during drought stress and subsequent recovery. Environ. Exp. Bot., 2007, 59, 117-129.
[http://dx.doi.org/10.1016/j.envexpbot.2005.10.001]
[41]
Sorkheh, K.; Shiran, B.; Rouhi, V.; Khodambashi, M.; Sofo, A. Salt stress induction of some key antioxidant enzymes and metabolites in eight Iranian wild almond species. Acta Physiol. Plant., 2012, 34, 203-213.
[http://dx.doi.org/10.1007/s11738-011-0819-4]
[42]
Siami, A.; Heidari, R.; Mohseni, M. Comparative study of amygdalin, fat and total protein of 7 species of wild almond in west Azerbaidjan (Iran). Acta Hortic., 2002, 181-187.
[http://dx.doi.org/10.17660/ActaHortic.2002.591.26]
[43]
Hosseinzadeh, M.; Moayedi, A.; Chudar Moghaddas, H.; Rezaei, K. Nutritional, anti-nutritional, and antioxidant properties of several wild almond species from iran. J. Agric. Sci. Technol., 2019, 21(2), 369-380.
[44]
Jang, G.H.; Kim, H.W.; Lee, M.K.; Jeong, S.Y.; Bak, A.R.; Lee, D.J.; Kim, J.B. Characterization and quantification of flavonoid glycosides in the Prunus genus by UPLC-DAD-QTOF/MS. Saudi J. Biol. Sci., 2018, 25(8), 1622-1631.
[http://dx.doi.org/10.1016/j.sjbs.2016.08.001] [PMID: 30591779]
[45]
Mirzapour, M.; Rezaei, K.; Sentandreu, M.A.; Moosavi-Movahedi, A.A. In vitro antioxidant activities of hydrolysates obtained from Iranian wild almond (Amygdalus scoparia) protein by several enzymes. Int. J. Food Sci. Technol., 2016, 51(3), 609-616.
[http://dx.doi.org/10.1111/ijfs.12996]
[46]
Mirzapour, M.; Rezaei, K.; Sentandreu, M.A. Identification of potent ACE inhibitory peptides from wild almond proteins. J. Food Sci., 2017, 82(10), 2421-2431.
[http://dx.doi.org/10.1111/1750-3841.13840] [PMID: 28833139]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy