Background: Acne Vulgaris a chronic disease which is caused by blockage of the sebaceous gland is commonly seen in almost every human being at some point of their lives. There are 20-25% chances of progression of acne to severe case which leads to permanent scarring that results in psychological problems like depression, social isolation, lowered self-esteem, and lowered self-confidence.
Objective: Though several conventional treatments are available in the market but still there are various adverse effects associated with topical antiacne agents due to which it lacks in patient compatibility. The present study is undertaken to find out the major shortcomings like why the current therapies are lacking in giving the desired therapeutic results.
Conclusion: Novel drug delivery strategies can play a crucial role in the enhancement of topical delivery of antiacne agents by escalating their dermal localization and reducing their adverse effects. Consumption of medicinal plants like Aloe vera, Withania somniferia etc. have clinical evidences regarding the effective management of acne. The current inclination towards nanotechnology is considerable due to several changes in the pharmaceutical research area. To secure the research work in different pharmaceutical fields patents are filed against various agents like Galderma Research & Development have filed for adapalene and benzoyl peroxide for the management of acne vulgaris. The current review highlights the potential of various novel drug delivery approaches like liposomes, niosomes, ethosomes, transfersomes etc. in enhancing the topical delivery of antiacne agents.