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Current Drug Therapy

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ISSN (Print): 1574-8855
ISSN (Online): 2212-3903

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Research Article

Development and Characterization of LBG-PVA Interpenetrating Networks Incorporating Gliclazide for Sustained Release

Author(s): Ashish Katoch, Manju Nagpal*, Malkiet Kaur, Manjinder Singh, Geeta Aggarwal and Gitika Arora Dhingra

Volume 16, Issue 1, 2021

Published on: 19 July, 2020

Page: [54 - 63] Pages: 10

DOI: 10.2174/1574885515999200719143513

Price: $65

Abstract

Background: Controlled oral dosage forms have always been preferred for drugs with variable absorption, and short biological half life and frequent dosing. The prime goal with sustained release systems is to maintain uniform therapeutic blood levels for more extended periods of time. Interpenetrating networks (IPNs) have been evidenced as uniform sustained release systems. In the current study, polyvinyl alcohol (PVA) and locust bean gum (LBG) based IPNs were developed for the oral sustained release drug delivery of gliclazide (shows variable absorption).

Methods: The IPNs were synthesized by emulsion cross-linking method using glutaraldehyde (GA) as a cross linking agent. Gliclazide is a potential second generation, and short-acting sulfonylurea oral hypoglycemic agent having a short biological half-life (2-4 h), variable absorption and poor oral bioavailability. Various batches of IPNs were formulated by varying LBG: PVA ratio and evaluated for percentage yield, drug entrapment efficiency (DEE), swelling properties and in vitro drug release studies. Further characterizations were done by Fourier Transform Infrared Spectroscopy (FTIR), C13 Solid state NMR, X-Ray diffraction study (XRD), Scanning electron microscopy (SEM), and Differential scanning microscopy (DSC) studies.

Results: The percentage yield, drug entrapment and equilibrium swelling were observed to be dependent on PVA-LBG ratio and GA amount. Sustained release of drug was observed in all IPN formulations (approx 59 - 86% in 8 h in various batches) with variable release kinetics. SEM studies revealed the regular structures of IPNs. FTIR, XRD, C13 Solid state NMR and DSC studies proposed that drug was successfully incorporated into the formed IPNs.

Conclusion: IPNs of LBG and PVA can be used as a promising carrier with uniform sustained release characteristics.

Keywords: Sustained, interpenetrating networks, cross-linker, networks, bioavailability, dissolution.

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[1]
Sperling LH, Hu R. Interpenetrating polymer networks polymer blends handbook 2003; 417-7.
[http://dx.doi.org/10.1007/0-306-48244-4_6]
[2]
Ignat L, Stanciu A. Advanced polymers: interpenetrating polymer networks handbook of polymer blends and composites 2003; 3: pp 275-280.
[3]
Work WJ, Horie K, Hess M, Stepto RF. Definition of terms related to polymer blends, composites, and multiphase polymeric materials (IUPAC Recommendations 2004). Pure Appl Chem 2004; 76(11): 1985-2007.
[http://dx.doi.org/10.1351/pac200476111985]
[4]
Pal D, Nayak AK, Saha S. Cellulose-based hydrogels: present and future innatural bio-active compounds. Singapore: Springer 2019; pp. 285-332.
[http://dx.doi.org/10.1007/978-981-13-7154-7_10]
[5]
Changez M, Burugapalli K, Koul V, Choudhary V. The effect of composition of poly(acrylic acid)-gelatin hydrogel on gentamicin sulphate release: in vitro. Biomaterials 2003; 24(4): 527-36.
[http://dx.doi.org/10.1016/S0142-9612(02)00364-2] [PMID: 12437947]
[6]
Upadhyay M, Adena SKR, Vardhan H, Pandey S, Mishra B. Development and optimization of locust bean gum and sodium alginate interpenetrating polymeric network of capecitabine. Drug Dev Ind Pharm 2018; 44(3): 511-21.
[http://dx.doi.org/10.1080/03639045.2017.1402921 PMID: 29161913]
[7]
Kaity S, Isaac J, Ghosh A. Interpenetrating polymer network of locust bean gum-poly (vinyl alcohol) for controlled release drug delivery. Carbohydr Polym 2013; 94(1): 456-67.
[http://dx.doi.org/10.1016/j.carbpol.2013.01.070 PMID: 23544563]
[8]
Jana S, Sen KK. Chitosan-Locust bean gum interpenetrating polymeric network nanocomposites for delivery of aceclofenac Int J bio macromolecules 2017; 102: 878-4.
[9]
Gupta NV, Satish CS, Shivakumar HG. Preparation and characterization of gelatin-poly (methacrylic acid) interpenetrating polymeric network hydrogels as a pH-sensitive delivery system for glipizide. Indian J Pharm Sci 2007; 69(1): 64.
[http://dx.doi.org/10.4103/0250-474X.32110]
[10]
Boppana R, Raut SY, Mohan GK, et al. Novel pH-sensitive interpenetrated network polyspheres of polyacrylamide-g-locust bean gum and sodium alginate for intestinal targeting of ketoprofen: In vitro and in vivo evaluation. Colloids Surf B Biointerfaces 2019; 180: 362-70.
[http://dx.doi.org/10.1016/j.colsurfb.2019.04.060 PMID: 31077864]
[11]
Jain N, Kumar H, Rajpoot AK, Verma HC. Novel interpenetrating mucoadhesive networks of locust bean gum and poly(vinyl alcohol) for the delivery of famotidine. MIT. Int J Pharma Sci 2015; 1(1): 27-36.
[12]
Madhavi C, Babu PK, Maruthi Y, Parandhama A, Reddy OS, Rao KC. Sodium alginate €“ locust bean gum IPN hydrogel beads for the controlled delivery of nimesulide-anti-inflammatory drug. Int J Pharm Pharm Sci 2017; 9: 245-52.
[http://dx.doi.org/10.22159/ijpps.2017v9i10.20231]
[13]
Sarkar A, Tiwari A, Bhasin PS, Mitra M. Pharmacological and pharmaceutical profile of gliclazide: a review. J Appl Pharm Sci 2011; 1(09): 11-9.
[14]
Rojanasthien N, Autsavakitipong T, Kumsorn B, Manorot M, Teekachunhatean S. Bioequivalence study of modified-release Gliclazide tablets in healthy volunteers Int Schol Res Noti 2012; 2012. Article ID 375134.
[http://dx.doi.org/10.5402/2012/375134]
[15]
Bajpai SK, Chand N, Agrawal A. Carboxymethylpsyllium (CMPsy)/poly (acrylamide)(poly (AAm)) hydrogels for oral delivery of anti-diabetic drug Gliclazide. J Macromolecular Sci. Part A 2017; 54(4): 221-7.
[http://dx.doi.org/10.1080/10601325.2017.1282233]
[16]
Swapna K, Kothamasu S, Swain S. Formulation and evaluation of Gliclazide sustained release tablets. Pharma Innova J 2018; 7(7): 649-54.
[17]
Dey P, Maiti S, Sa B. Gastrointestinal delivery of glipizide from carboxymethyl locust bean gum-Al3+ –alginate hydrogel network: In vitro and in vivo performance. J Appl Polym Sci 2013; 128(3): 2063-72.
[18]
Somya G, Nayyar P, Akanksha B, Kumar SP. Interpenetrating polymer network-based drug delivery systems: emerging applications and recent patents. Egyptian Pharma J 2015; 14(2): 75.
[http://dx.doi.org/10.4103/1687-4315.161266]
[19]
Kulkarni RV, Baraskar VV, Alange VV, Naikawadi AA, Sa B. Controlled release of an antihypertensive drug through interpenetrating polymer network hydrogel tablets of tamarind seed polysaccharide and sodium alginate. J Macromolecular Sci. Part B 2013; 52(11): 1636-50.
[http://dx.doi.org/10.1080/00222348.2013.789327]
[20]
Lohani A, Singh G, Bhattacharya SS, Verma A. Interpenetrating polymer networks as innovative drug delivery systems. J Drug Del 2014; 2014583612
[21]
Rokhade AP, Shelke NB, Patil SA, Aminabhavi TM. Novel interpenetrating polymer network networks of chitosan and methylcellulose for controlled release of theophylline. Carbohydr Polym 2007; 69(4): 678-87.
[http://dx.doi.org/10.1016/j.carbpol.2007.02.008]
[22]
Shoaib MH, Tazeen J, Merchant HA, Yousuf RI. Evaluation of drug release kinetics from ibuprofen matrix tablets using HPMC. Pak J Pharm Sci 2006; 19(2): 119-24.
[PMID: 16751122]

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