Generic placeholder image

Current Analytical Chemistry

Editor-in-Chief

ISSN (Print): 1573-4110
ISSN (Online): 1875-6727

Mini-Review Article

Multiple Heart-Cutting Two-Dimensional Liquid Chromatography: Recent Developments and Applications

Author(s): Brynish R. Dsouza, Alex Joseph*, Subham Das and Angel T. Alex

Volume 17, Issue 3, 2021

Published on: 30 June, 2020

Page: [339 - 354] Pages: 16

DOI: 10.2174/1573411016666200630114826

Price: $65

Abstract

Background: Over the last few decades, there has been a growing interest in Two- Dimensional Liquid Chromatography (2D-LC). This advanced technology has become a relevant solution for solving all the analytical challenges encountered in the pharmaceutical industry. The primary purpose of this review is to give a brief account of the developing techniques notable in 2D-LC.

Methods: Review of recent literature on advanced separation techniques for complex mixtures revealed that 2D-LC is the most widely used technique in the pharmaceutical laboratory for the separation of complex samples. Among the various techniques used in 2D-LC, comprehensive 2D-LC and heart-cutting 2D-LC are highly used techniques. To enhance the resolution, further development has been made to heart-cutting 2D-LC called multiple heart-cutting 2D-LC, which has recently become a very popular technique in the pharmaceutical industry. Therefore research articles mentioning the use of multiple heart-cutting 2D-LC for separation of complex mixtures were reviewed.

Results: The most crucial benefit of multiple heart-cutting 2D-LC is its reduced effort in method development and also the storage of multiple sample sections for further analysis. The multiple heartcutting 2D-LC is suited, preferably for method development and impurity analysis of pharmaceutical substances, fine chemicals and offers better peak separation, which is otherwise not possible by comprehensive 2D-LC.

Conclusion: The advantage of two-dimensional liquid chromatography over one-dimensional liquid chromatography is its high resolving power. Further improvement in resolution was achieved by using the advanced multiple heart-cutting 2D-LC which appears to have an imperative role in pharmaceutical and food analysis.

Keywords: Analytical, heart-cutting, liquid chromatography, one-dimensional, pharmaceutical, two-dimensional.

Graphical Abstract
[1]
Giddings, J.C.; Roy, A.K. Chromatography | Chemistry | Britannica,, https://www.britannica.com/science/chromatography
[2]
Police, T. Chromatography What Is It?, 2018.
[5]
Bhattacharyya, S.; Rana, D.; Bhattacharyya, S.N. A Thermodynamic Study of molecular association by gas-liquid chromatography: Trilaurylaminealcohol systems. J. Indian Chem. Soc., 1997, 74(7), 548-551.
[6]
Davis, J.M.; Giddings, J.C. Statistical theory of component overlap in multicomponent chromatograms. Anal. Chem., 1983, 55(3), 418-424.
[http://dx.doi.org/10.1021/ac00254a003]
[7]
Pirok, B.W.J.; Stoll, D.R.; Schoenmakers, P.J. Recent developments in two-dimensional liquid chromatography: Fundamental improvements for practical applications. Anal. Chem., 2019, 91(1), 240-263.
[http://dx.doi.org/10.1021/acs.analchem.8b04841] [PMID: 30380827]
[8]
Davis, J.M.; Stoll, D.R. Likelihood of total resolution in liquid chromatography: evaluation of one-dimensional, comprehensive two-dimensional, and selective comprehensive two-dimensional liquid chromatography. J. Chromatogr. A, 2014, 1360, 128-142.
[http://dx.doi.org/10.1016/j.chroma.2014.07.066] [PMID: 25108764]
[9]
Stoll, D.R.; Carr, P.W. Two-Dimensional liquid chromatography: A state of the art tutorial. Anal. Chem., 2017, 89(1), 519-531.
[http://dx.doi.org/10.1021/acs.analchem.6b03506] [PMID: 27935671]
[10]
Filgueira, M.R.; Huang, Y.; Witt, K.; Castells, C.; Carr, P.W. Improving peak capacity in fast online comprehensive two-dimensional liquid chromatography with post-first-dimension flow splitting. Anal. Chem., 2011, 83(24), 9531-9539.
[http://dx.doi.org/10.1021/ac202317m] [PMID: 22017622]
[11]
Stoll, D.R.; Cohen, J.D.; Carr, P.W. Fast, comprehensive online two-dimensional high performance liquid chromatography through the use of high temperature ultra-fast gradient elution reversed-phase liquid chromatography. J. Chromatogr. A, 2006, 1122(1-2), 123-137.
[http://dx.doi.org/10.1016/j.chroma.2006.04.058] [PMID: 16720027]
[12]
Murphy, R.E.; Schure, M.R.; Foley, J.P. One- and two-dimensional chromatographic analysis of alcohol ethoxylates. Anal. Chem., 1998, 70(20), 4353-4360.
[http://dx.doi.org/10.1021/ac980180j]
[13]
Stoll, D.R.; Li, X.; Wang, X.; Carr, P.W.; Porter, S.E.G.; Rutan, S.C. Fast, comprehensive two-dimensional liquid chromatography. J. Chromatogr. A, 2007, 1168(1-2), 3-43.
[http://dx.doi.org/10.1016/j.chroma.2007.08.054] [PMID: 17888443]
[14]
Pursch, M.; Buckenmaier, S. Loop-based multiple heart-cutting two-dimensional liquid chromatography for target analysis in complex matrices. Anal. Chem., 2015, 87(10), 5310-5317.
[http://dx.doi.org/10.1021/acs.analchem.5b00492] [PMID: 25897943]
[15]
van der Horst, A.; Schoenmakers, P.J. Comprehensive two-dimensional liquid chromatography of polymers. J. Chromatogr. A, 2003, 1000(1-2), 693-709.
[http://dx.doi.org/10.1016/S0021-9673(03)00495-3 PMID: 12877195]
[16]
Stoll, D.R.; Venkatramani, C.J.; Rutan, S.C. Peak purity in liquid chromatography, part III: Using two-dimensional liquid chromatography. LC GC N. Am., 2018, 36(6), 356-361.
[17]
Yang, S.H.; Wang, J.; Zhang, K. Validation of a two-dimensional liquid chromatography method for quality control testing of pharmaceutical materials. J. Chromatogr. A, 2017, 1492, 89-97.
[http://dx.doi.org/10.1016/j.chroma.2017.02.074] [PMID: 28284763]
[18]
Sheng, Y.; Zhou, B. High-throughput determination of vancomycin in human plasma by a cost-effective system of two-dimensional liquid chromatography. J. Chromatogr. A, 2017, 1499, 48-56.
[http://dx.doi.org/10.1016/j.chroma.2017.02.061] [PMID: 28420531]
[19]
Chen, M.; Wang, L.; Dong, H.; Shao, X.; Wu, D.; Liu, B.; Zhang, X.; Chen, C. Quantitative method for analysis of tobacco-specific N-nitrosamines in mainstream cigarette smoke by using heart-cutting two-dimensional liquid chromatography with tandem mass spectrometry. J. Sep. Sci., 2017, 40(9), 1920-1927.
[http://dx.doi.org/10.1002/jssc.201601367] [PMID: 28266176]
[20]
Wang, S.; Zhou, L.; Wang, Z.; Shi, X.; Xu, G. Simultaneous metabolomics and lipidomics analysis based on novel heart-cutting two-dimensional liquid chromatography-mass spectrometry. Anal. Chim. Acta, 2017, 966, 34-40.
[http://dx.doi.org/10.1016/j.aca.2017.03.004] [PMID: 28372724]
[21]
Sandra, K.; Steenbeke, M.; Vandenheede, I.; Vanhoenacker, G.; Sandra, P. The versatility of heart-cutting and comprehensive two-dimensional liquid chromatography in monoclonal antibody clone selection. J. Chromatogr. A, 2017, 1523, 283-292.
[http://dx.doi.org/10.1016/j.chroma.2017.06.052] [PMID: 28668371]
[22]
Zhang, Y.; Carr, P.W. A visual approach to stationary phase selectivity classification based on the Snyder-Dolan Hydrophobic-Subtraction Model. J. Chromatogr. A, 2009, 1216(39), 6685-6694.
[http://dx.doi.org/10.1016/j.chroma.2009.06.048] [PMID: 19700166]
[23]
Buckenmaier, S.; Freisler, U.; Anderer, H.; Trafkowski, J.; Shoykhet, K. (Choikhet), Klaus Witt, and M. D. Enhancing 2D-LC analysis using the multiple heart-cutting technology. Steroids, 2014, 74(2), 1-11.
[http://dx.doi.org/10.1017/CBO9781107415324.004]
[24]
van de Schans, M.G.M.; Blokland, M.H.; Zoontjes, P.W.; Mulder, P.P.J.; Nielen, M.W.F. Multiple heart-cutting two dimensional liquid chromatography quadrupole time-of-flight mass spectrometry of pyrrolizidine alkaloids. J. Chromatogr. A, 2017, 1503, 38-48.
[http://dx.doi.org/10.1016/j.chroma.2017.04.059] [PMID: 28487121]
[25]
Venkatramani, C.J.; Al-Sayah, M.; Li, G.; Goel, M.; Girotti, J.; Zang, L.; Wigman, L.; Yehl, P.; Chetwyn, N. Simultaneous achiral-chiral analysis of pharmaceutical compounds using two-dimensional reversed phase liquid chromatography-supercritical fluid chromatography. Talanta, 2016, 148, 548-555.
[http://dx.doi.org/10.1016/j.talanta.2015.10.054] [PMID: 26653484]
[26]
Barhate, C.L.; Regalado, E.L.; Contrella, N.D.; Lee, J.; Jo, J.; Makarov, A.A.; Armstrong, D.W.; Welch, C.J. Ultrafast chiral chromatography as the second dimension in two-dimensional liquid chromatography experiments. Anal. Chem., 2017, 89(6), 3545-3553.
[http://dx.doi.org/10.1021/acs.analchem.6b04834] [PMID: 28192943]
[27]
Sandra, K.; Vanhoenacker, G.; Vandenheede, I.; Steenbeke, M.; Joseph, M.; Sandra, P. Multiple heart-cutting and comprehensive two-dimensional liquid chromatography hyphenated to mass spectrometry for the characterization of the antibody-drug conjugate ado-trastuzumab emtansine. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2016, 1032, 119-130.
[http://dx.doi.org/10.1016/j.jchromb.2016.04.040] [PMID: 27160547]
[28]
Petersson, P.; Haselmann, K.; Buckenmaier, S. Multiple heart-cutting two dimensional liquid chromatography mass spectrometry: Towards real time determination of related impurities of bio-pharmaceuticals in salt based separation methods. J. Chromatogr. A, 2016, 1468, 95-101.
[http://dx.doi.org/10.1016/j.chroma.2016.09.023] [PMID: 27667648]
[29]
Stephan, S.; Jakob, C.; Hippler, J.; Schmitz, O.J. A novel four-dimensional analytical approach for analysis of complex samples. Anal. Bioanal. Chem., 2016, 408(14), 3751-3759.
[http://dx.doi.org/10.1007/s00216-016-9460-9] [PMID: 27038056]
[30]
Wang, X.; Buckenmaier, S.; Stoll, D. The growing role of two-dimensional LC in the biopharmaceutical industry. J. Appl. Bioanal., 2017, 3(5), 120-126.
[http://dx.doi.org/10.17145/jab.17.015]
[31]
Qiao, X.; Wang, Q.; Song, W.; Qian, Y.; Xiao, Y.; An, R.; Guo, D.A.; Ye, M. A chemical profiling solution for Chinese medicine formulas using comprehensive and loop-based multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J. Chromatogr. A, 2016, 1438, 198-204.
[http://dx.doi.org/10.1016/j.chroma.2016.02.034] [PMID: 26905883]
[32]
Martin, M.; Herman, D.P.; Guiochon, G. Probability distributions of the number of chromatographically resolved peaks and resolvable components in mixtures. Anal. Chem., 1986, 58(11), 2200-2207.
[http://dx.doi.org/10.1021/ac00124a019]
[33]
Jacobsen, N.W.; Nielsen, L.D. Two-Dimensional Liquid Chromatography (2D-LC) with Multiple Heart-Cutting. Eur. Pharm. Rev., 2017, 22(3), 60-63.
[34]
Simpkins, S.W.; Bedard, J.W.; Groskreutz, S.R.; Swenson, M.M.; Liskutin, T.E.; Stoll, D.R. Targeted three-dimensional liquid chromatography: A versatile tool for quantitative trace analysis in complex matrices. J. Chromatogr. A, 2010, 1217(49), 7648-7660.
[http://dx.doi.org/10.1016/j.chroma.2010.09.023] [PMID: 21047638]
[35]
Stoll, D.R. Introduction to Two-Dimensional Liquid Chromatography—Theory and Practice; Elsevier Inc., 2017.
[http://dx.doi.org/10.1016/B978-0-12-811732-3.00007-8]
[36]
Buckenmaier, S. Agilent 1290 Infi Nity 2D-LC Solution for Multiple Heart-Cutting; 5991-5615EN; Waldbronn: Germany, 2015.
[37]
Johnson, E.L.; Gloor, R.; Majors, R.E. Coupled column chromatography employing exclusion and a reversed phase. A potential general approach to sequential analysis. J. Chromatogr. A, 1978, 149(C), 571-585.
[http://dx.doi.org/10.1016/S0021-9673(00)81012-2]
[38]
Wouters, B.; Davydova, E.; Wouters, S.; Vivo-Truyols, G.; Schoenmakers, P.J.; Eeltink, S. Towards ultra-high peak capacities and peak-production rates using spatial three-dimensional liquid chromatography. Lab Chip, 2015, 15(23), 4415-4422.
[http://dx.doi.org/10.1039/C5LC01169H] [PMID: 26495444]
[39]
Giddings, J.C. Two-dimensional field-flow fractionation. J. Chromatogr. A, 1990, 504(2), 247-258.
[http://dx.doi.org/10.1016/S0021-9673(01)89530-3] [PMID: 2341520]
[40]
Vanhoenacker, G.; Sandra, K.; Vandenheede, I.; David, F. Analysis of monoclonal antibody digests with the agilent 1290 infinity 2DLC solution. Agil Tech., 2013. Available from:. https://grupobiomaster.com/wp-content/uploads/2015/05/5991-4530EN1.pdf
[41]
Guide, U. Gilent 1290 Infinity 2D-LC-Solution,, 2015.
[42]
Groskreutz, S.R.; Swenson, M.M.; Secor, L.B.; Stoll, D.R. Selective comprehensive multi-dimensional separation for resolution enhancement in high performance liquid chromatography. Part I: Principles and instrumentation. J. Chromatogr. A, 2012, 1228, 31-40.
[http://dx.doi.org/10.1016/j.chroma.2011.06.035] [PMID: 21802089]
[43]
Zhang, K.; Li, Y.; Tsang, M.; Chetwyn, N.P. Analysis of pharmaceutical impurities using multi-heartcutting 2D LC coupled with UV-charged aerosol MS detection. J. Sep. Sci., 2013, 36(18), 2986-2992.
[http://dx.doi.org/10.1002/jssc.201300493] [PMID: 23821312]
[44]
Groskreutz, S.R.; Swenson, M.M.; Secor, L.B.; Stoll, D.R. Selective comprehensive multidimensional separation for resolution enhancement in high performance liquid chromatography. Part II: Applications. J. Chromatogr. A, 2012, 1228, 41-50.
[http://dx.doi.org/10.1016/j.chroma.2011.06.038] [PMID: 21816400]
[45]
Guiochon, G.; Marchetti, N.; Mriziq, K.; Shalliker, R.A. Implementations of two-dimensional liquid chromatography. J. Chromatogr. A, 2008, 1189(1-2), 109-168.
[http://dx.doi.org/10.1016/j.chroma.2008.01.086] [PMID: 18336826]
[46]
Stoll, D.R. Recent advances in 2D-LC for bioanalysis. Bioanalysis, 2015, 7(24), 3125-3142.
[http://dx.doi.org/10.4155/bio.15.223] [PMID: 26626829]
[47]
Pirok, B.W.J.; Schoenmakers, P.J. Practical approaches to overcome the challenges of comprehensive two-dimensional liquid chromatography. LC GC Eur., 2018, 31(5), 242-249.
[48]
Thomas, E. Wheat; Charles H. Phoebe; Mark K. Baynham; Uwe Dieter Neue; Raymond P. Fisk; Richard C; Turner. Mobile phase dilution scheme for enhanced chromatography,, 2004.
[49]
Gargano, A.F.G.; Duffin, M.; Navarro, P.; Schoenmakers, P.J. Reducing dilution and analysis time in online comprehensive two-dimensional liquid chromatography by active modulation. Anal. Chem., 2016, 88(3), 1785-1793.
[http://dx.doi.org/10.1021/acs.analchem.5b04051] [PMID: 26709410]
[50]
Yang, P.; Pursch, M. Recent advances in two-dimensional liquid chromatography. Chromatogr. Today, 2018, 10(4), 24-29.
[51]
Mayfield, K.J.; Shalliker, R.A.; Catchpoole, H.J.; Sweeney, A.P.; Wong, V.; Guiochon, G. Viscous fingering induced flow instability in multidimensional liquid chromatography. J. Chromatogr. A, 2005, 1080(2), 124-131.
[http://dx.doi.org/10.1016/j.chroma.2005.04.093] [PMID: 16008050]
[52]
Samuelsson, J.; Shalliker, R.A.; Fornstedt, T. Viscosity contrast effects in analytical scale chromatography - evidence and impact. Microchem. J., 2017, 130, 102-107.
[http://dx.doi.org/10.1016/j.microc.2016.08.007]
[53]
François, I.; Sandra, K.; Sandra, P.; Dugo, P.; Mondello, L.; Cacciola, F.; Donato, P. Comprehensive two‐dimensional liquid chromatography combined with mass spectrometry. Compr. Chromatogr. Comb. Mass Spectr., 2011, 2011, 281-427.
[54]
Dugo, P.; Cacciola, F.; Kumm, T.; Dugo, G.; Mondello, L. Comprehensive multidimensional liquid chromatography: Theory and applications. J. Chromatogr. A, 2008, 1184(1-2), 353-368.
[http://dx.doi.org/10.1016/j.chroma.2007.06.074] [PMID: 17655853]
[55]
Shalliker, R.A.; Guiochon, G. Understanding the importance of the viscosity contrast between the sample solvent plug and the mobile phase and its potential consequence in two-dimensional high-performance liquid chromatography. J. Chromatogr. A, 2009, 1216(5), 787-793.
[http://dx.doi.org/10.1016/j.chroma.2008.11.067] [PMID: 19095236]
[56]
Jiang, X.; van der Horst, A.; Schoenmakers, P.J. Breakthrough of polymers in interactive liquid chromatography. J. Chromatogr. A, 2002, 982(1), 55-68.
[http://dx.doi.org/10.1016/S0021-9673(02)01483-8 PMID: 12489856]
[57]
Reingruber, E.; Jansen, J.J.; Buchberger, W.; Schoenmakers, P. Transfer-volume effects in two-dimensional chromatography: adsorption-phenomena in second-dimension size-exclusion chromatography. J. Chromatogr. A, 2011, 1218(8), 1147-1152.
[http://dx.doi.org/10.1016/j.chroma.2010.12.080] [PMID: 21227427]
[58]
Talus, E.S.; Witt, K.E.; Stoll, D.R. Effect of pressure pulses at the interface valve on the stability of second dimension columns in online comprehensive two-dimensional liquid chromatography. J. Chromatogr. A, 2015, 1378, 50-57.
[http://dx.doi.org/10.1016/j.chroma.2014.12.019] [PMID: 25553909]
[59]
Baglai, A.; Blokland, M.H.; Mol, H.G.J.; Gargano, A.F.G.; van der Wal, S.; Schoenmakers, P.J. Enhancing detectability of anabolic-steroid residues in bovine urine by actively modulated online comprehensive two-dimensional liquid chromatography - high-resolution mass spectrometry. Anal. Chim. Acta, 2018, 1013(1013), 87-97.
[http://dx.doi.org/10.1016/j.aca.2017.12.043] [PMID: 29501096]
[60]
Sommella, E.; Ismail, O.H.; Pagano, F.; Pepe, G.; Ostacolo, C.; Mazzoccanti, G.; Russo, M.; Novellino, E.; Gasparrini, F.; Campiglia, P. Development of an improved online comprehensive hydrophilic interaction chromatography × reversed-phase ultra-high-pressure liquid chromatography platform for complex multiclass polyphenolic sample analysis. J. Sep. Sci., 2017, 40(10), 2188-2197.
[http://dx.doi.org/10.1002/jssc.201700134] [PMID: 28349602]
[61]
Stoll, D.R.; Shoykhet, K.; Petersson, P.; Buckenmaier, S. Active solvent modulation: A valve-based approach to improve separation compatibility in two-dimensional liquid chromatography. Anal. Chem., 2017, 89(17), 9260-9267.
[http://dx.doi.org/10.1021/acs.analchem.7b02046] [PMID: 28724287]
[62]
Pursch, M.; Wegener, A.; Buckenmaier, S. Evaluation of active solvent modulation to enhance two-dimensional liquid chromatography for target analysis in polymeric matrices. J. Chromatogr. A, 2018, 1562, 78-86.
[http://dx.doi.org/10.1016/j.chroma.2018.05.059] [PMID: 29861307]
[63]
Fornells, E.; Barnett, B.; Bailey, M.; Shellie, R.A.; Hilder, E.F.; Breadmore, M.C. Membrane assisted and temperature controlled on-line evaporative concentration for microfluidics. J. Chromatogr. A, 2017, 1486, 110-116.
[http://dx.doi.org/10.1016/j.chroma.2016.12.003] [PMID: 28034502]
[64]
Stoll, D.R.; Harmes, D.C.; Staples, G.O.; Potter, O.G.; Dammann, C.T.; Guillarme, D.; Beck, A. Development of comprehensive online two-dimensional liquid chromatography/mass spectrometry using hydrophilic interaction and reversed-phase separations for rapid and deep profiling of therapeutic antibodies. Anal. Chem., 2018, 90(9), 5923-5929.
[http://dx.doi.org/10.1021/acs.analchem.8b00776] [PMID: 29614857]
[65]
Krieger, S. The Agilent InfinityLab 2D-LC Solution with Active Solvent Modulation Achieving Improved Resolution and Sensitivity for Challenging Combinations of Separation Conditions 2017, 5991-8785E. Available from:. https://www.agilent.com/cs/library/technicaloverviews/public/5991-8785EN_2DLC_ASM_technicaloverview.pdf
[66]
Stoll, D.R.; Sajulga, R.W.; Voigt, B.N.; Larson, E.J.; Jeong, L.N.; Rutan, S.C. Simulation of elution profiles in liquid chromatography - II: Investigation of injection volume overload under gradient elution conditions applied to second dimension separations in two-dimensional liquid chromatography. J. Chromatogr. A, 2017, 1523, 162-172.
[http://dx.doi.org/10.1016/j.chroma.2017.07.041] [PMID: 28747254]
[67]
Jeong, L.N.; Sajulga, R.; Forte, S.G.; Stoll, D.R.; Rutan, S.C. Simulation of elution profiles in liquid chromatography-I: Gradient elution conditions, and with mismatched injection and mobile phase solvents. J. Chromatogr. A, 2016, 1457, 41-49.
[http://dx.doi.org/10.1016/j.chroma.2016.06.016] [PMID: 27345210]
[68]
Bäurer, S.; Guo, W.; Polnick, S.; Lämmerhofer, M. Simultaneous separation of water- and fat-soluble vitamins by selective comprehensive HILIC × RPLC (High-Resolution Sampling) and active solvent modulation. Chromatographia, 2019, 82(1), 167-180.
[http://dx.doi.org/10.1007/s10337-018-3615-0]
[69]
Yang, P.; Gao, W.; Zhang, T.; Pursch, M.; Luong, J.; Sattler, W.; Singh, A.; Backer, S. Two-dimensional liquid chromatography with active solvent modulation for studying monomer incorporation in copolymer dispersants. J. Sep. Sci., 2019, 42(17), 2805-2815.
[http://dx.doi.org/10.1002/jssc.201900283] [PMID: 31250527]
[70]
Vonk, R.J.; Gargano, A.F.G.; Davydova, E.; Dekker, H.L.; Eeltink, S.; de Koning, L.J.; Schoenmakers, P.J. Comprehensive two-dimensional liquid chromatography with stationary-phase-assisted modulation coupled to high-resolution mass spectrometry applied to proteome analysis of Saccharomyces cerevisiae. Anal. Chem., 2015, 87(10), 5387-5394.
[http://dx.doi.org/10.1021/acs.analchem.5b00708] [PMID: 25894977]
[71]
Ianovska, M.A.; Mulder, P.P.M.F.A.; Verpoorte, E. Development of small-volume, microfluidic chaotic mixers for future application in two-dimensional liquid chromatography. RSC Advances, 2017, 7(15), 9090-9099.
[http://dx.doi.org/10.1039/C6RA28626G]
[72]
Toro-Uribe, S.; Montero, L.; López-Giraldo, L.; Ibáñez, E.; Herrero, M. Characterization of secondary metabolites from green cocoa beans using focusing-modulated comprehensive two-dimensional liquid chromatography coupled to tandem mass spectrometry. Anal. Chim. Acta, 2018, 1036, 204-213.
[http://dx.doi.org/10.1016/j.aca.2018.06.068] [PMID: 30253833]
[73]
Goel, M.; Larson, E.; Venkatramani, C.J.; Al-Sayah, M.A. Optimization of a two-dimensional liquid chromatography-supercritical fluid chromatography-mass spectrometry (2D-LC-SFS-MS) system to assess “in-vivo” inter-conversion of chiral drug molecules. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2018, 1084, 89-95.
[http://dx.doi.org/10.1016/j.jchromb.2018.03.029] [PMID: 29579733]
[74]
Pirok, B.W.J.; Gargano, A.F.G.; Schoenmakers, P.J. Optimizing separations in online comprehensive two-dimensional liquid chromatography. J. Sep. Sci., 2018, 41(1), 68-98.
[http://dx.doi.org/10.1002/jssc.201700863] [PMID: 29027363]
[75]
Jakobsen, S.S.; Christensen, J.H.; Verdier, S.; Mallet, C.R.; Nielsen, N.J. Increasing flexibility in two-dimensional liquid chromatography by pulsed elution of the first dimension: A proof of concept. Anal. Chem., 2017, 89(17), 8723-8730.
[http://dx.doi.org/10.1021/acs.analchem.7b00758] [PMID: 28758730]
[76]
Pirok, B.W.J.; Abdulhussain, N.; Aalbers, T.; Wouters, B.; Peters, R.A.H.; Schoenmakers, P.J. Nanoparticle analysis by online comprehensive two-dimensional liquid chromatography combining hydrodynamic chromatography and size-exclusion chromatography with intermediate sample transformation. Anal. Chem., 2017, 89(17), 9167-9174.
[http://dx.doi.org/10.1021/acs.analchem.7b01906] [PMID: 28745485]
[77]
Callister, S.J.; Fillmore, T.L.; Nicora, C.D.; Shaw, J.B.; Purvine, S.O.; Orton, D.J.; White, R.A.; Moore, R.J.; Burnet, M.C.; Nakayasu, E.S.; Payne, S.H.; Jansson, J.K.; Paša-Tolić, L. Addressing the challenge of soil metaproteome complexity by improving metaproteome depth of coverage through two-dimensional liquid chromatography. Soil Biol. Biochem., 2018, 125(February), 290-299.
[http://dx.doi.org/10.1016/j.soilbio.2018.07.018]
[78]
Gargano, A.F.G.; Shaw, J.B.; Zhou, M.; Wilkins, C.S.; Fillmore, T.L.; Moore, R.J.; Somsen, G.W.; Paša-Tolić, L. Increasing the separation capacity of intact histone proteoforms chromatography coupling online weak cation exchange-HILIC to reversed phase LC UVPD-HRMS. J. Proteome Res., 2018, 17(11), 3791-3800.
[http://dx.doi.org/10.1021/acs.jproteome.8b00458] [PMID: 30226781]
[79]
Tian, H.; Xu, J.; Xu, Y.; Guan, Y. Multidimensional liquid chromatography system with an innovative solvent evaporation interface. J. Chromatogr. A, 2006, 1137(1), 42-48.
[http://dx.doi.org/10.1016/j.chroma.2006.10.005] [PMID: 17084846]
[80]
Tian, H.; Xu, J.; Guan, Y. Comprehensive two-dimensional liquid chromatography (NPLCxRPLC) with vacuum-evaporation interface. J. Sep. Sci., 2008, 31(10), 1677-1685.
[http://dx.doi.org/10.1002/jssc.200700559] [PMID: 18481322]
[81]
Shen, S.; Yang, L.; Li, L.; Bai, Y.; Cai, C.; Liu, H. A plasma lipidomics strategy reveals perturbed lipid metabolic pathways and potential lipid biomarkers of human colorectal cancer. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2017, 1068-1069(February), 41-48.
[http://dx.doi.org/10.1016/j.jchromb.2017.10.004] [PMID: 29028617]
[82]
Weng, R.; Shen, S.; Burton, C.; Yang, L.; Nie, H.; Tian, Y.; Bai, Y.; Liu, H. Lipidomic profiling of tryptophan hydroxylase 2 knockout mice reveals novel lipid biomarkers associated with serotonin deficiency. Anal. Bioanal. Chem., 2016, 408(11), 2963-2973.
[http://dx.doi.org/10.1007/s00216-015-9256-3] [PMID: 26780709]
[83]
Impurities in New Drug Substances. ICH Harmon. Tripart. Guidel; No. October, 2006.
[84]
Naegele, E. Detection of impurities by heart cutting using the agilent 1290 Infinity 2D-LC Solution Agil; Technol. Appl. Note, 2012.
[85]
Schneider, S.; Naegele, E.; Krieger, S. Online 2D-LC Analysis of Complex N-Glycans in Biopharmaceuticals Using the Agilent 1290 Infi Nity 2D-LC Solution, 2017.
[86]
Krieger, S. Application of Multiple Heart-Cutting 2D-LC in Method Development for Impurity Analysis. The Agilent 1290 Infi nity 2D-LC Solution, 2015. Available from:. https://www.agilent.com/cs/library/applications/5991-5643EN.pdf
[87]
Németh, T.; Haghedooren, E.; Noszál, B.; Hoogmartens, J.; Adams, E. Three methods to characterize reversed phase liquid chromatographic columns applied to pharmaceutical separations. J. Chemometr., 2008, 22(3-4), 178-185.
[http://dx.doi.org/10.1002/cem.1108]
[88]
Li, Y.; Stella, C.; Zheng, L.; Bechtel, C.; Gruenhagen, J.; Jacobson, F.; Medley, C.D. Investigation of low recovery in the free drug assay for antibody drug conjugates by size exclusion-reversed phase two dimensional-liquid chromatography. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2016, 1032, 112-118.
[http://dx.doi.org/10.1016/j.jchromb.2016.05.011] [PMID: 27212187]
[89]
Venkatramani, C.J.; Huang, S.R.; Al-Sayah, M.; Patel, I.; Wigman, L. High-resolution two-dimensional liquid chromatography analysis of key linker drug intermediate used in antibody drug conjugates. J. Chromatogr. A, 2017, 1521, 63-72.
[http://dx.doi.org/10.1016/j.chroma.2017.09.022] [PMID: 28942996]
[90]
Beck, A.; Terral, G.; Debaene, F.; Wagner-Rousset, E.; Marcoux, J.; Janin-Bussat, M.C.; Colas, O.; Van Dorsselaer, A.; Cianférani, S. Cutting-edge mass spectrometry methods for the multi-level structural characterization of antibody-drug conjugates. Expert Rev. Proteomics, 2016, 13(2), 157-183.
[http://dx.doi.org/10.1586/14789450.2016.1132167 PMID: 26653789]
[91]
Chen, T.; Chen, Y.; Stella, C.; Medley, C.D.; Gruenhagen, J.A.; Zhang, K. Antibody-drug conjugate characterization by chromatographic and electrophoretic techniques. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2016, 1032, 39-50.
[http://dx.doi.org/10.1016/j.jchromb.2016.07.023] [PMID: 27451254]
[92]
Stoll, D.R.; Maloney, T.D. Recent Advances in Two-Dimensional Liquid Chromatography for Pharmaceutical and Biopharmaceutical Analysis.Available from:, http://www.chromatographyonline.com/recent-advances-two-dimensional-liquid-chromatography-pharmaceutical-and-biopharmaceutical-analysis
[93]
Luo, H.; Zhong, W.; Yang, J.; Zhuang, P.; Meng, F.; Caldwell, J.; Mao, B.; Welch, C.J. 2D-LC as an on-line desalting tool allowing peptide identification directly from MS unfriendly HPLC methods. J. Pharm. Biomed. Anal., 2017, 137, 139-145.
[http://dx.doi.org/10.1016/j.jpba.2016.11.012] [PMID: 28113090]
[94]
Alexander, A.J.; Ma, L. Comprehensive two-dimensional liquid chromatography separations of pharmaceutical samples using dual Fused-Core columns in the 2nd dimension. J. Chromatogr. A, 2009, 1216(9), 1338-1345.
[http://dx.doi.org/10.1016/j.chroma.2008.12.063] [PMID: 19150719]
[95]
Sarrut, M.; Corgier, A.; Fekete, S.; Guillarme, D.; Lascoux, D.; Janin-Bussat, M.C.; Beck, A.; Heinisch, S. Analysis of antibody-drug conjugates by comprehensive on-line two-dimensional hydrophobic interaction chromatography x reversed phase liquid chromatography hyphenated to high resolution mass spectrometry. I - Optimization of separation conditions. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2016, 1032, 103-111.
[http://dx.doi.org/10.1016/j.jchromb.2016.06.048] [PMID: 27426266]
[96]
Williams, A.; Read, E.K.; Agarabi, C.D.; Lute, S.; Brorson, K.A. Automated 2D-HPLC method for characterization of protein aggregation with in-line fraction collection device. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci., 2017, 1046, 122-130.
[http://dx.doi.org/10.1016/j.jchromb.2017.01.021] [PMID: 28178596]
[97]
Gstöttner, C.; Klemm, D.; Haberger, M.; Bathke, A.; Wegele, H.; Bell, C.; Kopf, R. Fast and automated characterization of antibody variants with 4D HPLC/MS. Anal. Chem., 2018, 90(3), 2119-2125.
[http://dx.doi.org/10.1021/acs.analchem.7b04372] [PMID: 29264912]
[98]
Goyon, A.; Sciascera, L.; Clarke, A.; Guillarme, D.; Pell, R. Extending the limits of size exclusion chromatography: Simultaneous separation of free payloads and related species from antibody drug conjugates and their aggregates. J. Chromatogr. A, 2018, 1539, 19-29.
[http://dx.doi.org/10.1016/j.chroma.2018.01.039] [PMID: 29397979]
[99]
Birdsall, R.E.; McCarthy, S.M.; Janin-Bussat, M.C.; Perez, M.; Haeuw, J.F.; Chen, W.; Beck, A. A sensitive multidimensional method for the detection, characterization, and quantification of trace free drug species in antibody-drug conjugate samples using mass spectral detection. MAbs, 2016, 8(2), 306-317.
[http://dx.doi.org/10.1080/19420862.2015.1116659 PMID: 26651262]
[100]
Wald, G.; Pursch, M.; Gu, B. .Multiple Heart-Cutting 2D LC for challenging separation problems, 2016. Available from:, https://www.agilent.com/cs/library/posters/public/Multiple_Heart-Cutting_2D-LC_For_Challenging_Separation_Problems.pdf
[101]
Qi, D.; Fei, T.; Liu, H.; Yao, H.; Wu, D.; Liu, B. Development of multiple heart-cutting two-dimensional liquid chromatography coupled to quadrupole-orbitrap high resolution mass spectrometry for simultaneous determination of aflatoxin b1, b2, g1, g2, and ochratoxin A in Snus, a smokeless tobacco product. J. Agric. Food Chem., 2017, 65(45), 9923-9929.
[http://dx.doi.org/10.1021/acs.jafc.7b04329] [PMID: 29065690]
[102]
Di Palma, S.; Hennrich, M.L.; Heck, A.J.R.; Mohammed, S. Recent advances in peptide separation by multidimensional liquid chromatography for proteome analysis. J. Proteomics, 2012, 75(13), 3791-3813.
[http://dx.doi.org/10.1016/j.jprot.2012.04.033] [PMID: 22561838]
[103]
Sandra, K.; Sandra, P.; Vandenheede, I. the power of liquid chromatography-mass spectrometry in the characterization of protein biopharmaceuticals. LC GC Eur., 2013, 26(5)(Suppl.), 10-16.
[104]
Ouyang, Y.; Zeng, Y.; Rong, Y.; Song, Y.; Shi, L.; Chen, B.; Yang, X.; Xu, N.; Linhardt, R.J.; Zhang, Z. Profiling analysis of low molecular weight heparins by multiple heart-cutting two dimensional chromatography with quadruple time-of-flight mass spectrometry. Anal. Chem., 2015, 87(17), 8957-8963.
[http://dx.doi.org/10.1021/acs.analchem.5b02218] [PMID: 26222954]
[105]
Vanhoenacker, G.; Vandenheede, I.; David, F.; Sandra, P.; Sandra, K. Comprehensive two-dimensional liquid chromatography of therapeutic monoclonal antibody digests. Anal. Bioanal. Chem., 2015, 407(1), 355-366.
[http://dx.doi.org/10.1007/s00216-014-8299-1] [PMID: 25410642]
[106]
Sheng, N.; Zheng, H.; Xiao, Y.; Wang, Z.; Li, M.; Zhang, J. Chiral separation and chemical profile of Dengzhan Shengmai by integrating comprehensive with multiple heart-cutting two-dimensional liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. J. Chromatogr. A, 2017, 1517, 97-107.
[http://dx.doi.org/10.1016/j.chroma.2017.08.037] [PMID: 28847584]

Rights & Permissions Print Cite
© 2024 Bentham Science Publishers | Privacy Policy