Recent Achievement in the Synthesis of Benzo[b]furans

(E-pub Ahead of Print)

Author(s): Dau Xuan Duc*

Journal Name: Current Organic Synthesis

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Background: Benzo[b]furan derivatives are oxygen-containing heterocyclic compounds consisting of fused benzene and furan rings and present in a large number of natural and non-natural compounds. This class of compounds has a wide spectrum of biological activities such as antiarrhythmic, anticancer, inflammatory, antioxidant, antimicrobial, and antiviral activity. Furthermore, benzo[b]furan derivatives have also been applied in various areas such as organic electroluminescence device materials and organic dyes, photosensitizing material, organic synthesis as building blocks or intermediates. Because of a broad range of applicability, the synthesis of benzo[b]furan derivative has drawn great attention of chemists and many studies on the synthesis of this class of compounds have been reported recently. This review will give an overview of benzo[b]furan preparation based on studies dating back to 2012.

Objective: In this review, i discussed recent development in the synthesis of benzo[b]furans. There has been increasing new methodology for the construction of benzo[b]furans skeleton to improve efficiency or use environmentally friendly procedure. In some studies, reaction mechanisms were also outlined.

Conclusion: Many methods for the synthesis of benzo[b]furans have been reported recently. Most of them involve to cyclization or cycloisomerization processes. Unquestionably, more imaginative strategies for the construction of benzo[b]furan skeleton will be established in the near future. Application of known method to natural product or drug synthesis, industrial scale for the synthesis of economically or medicinally important benzo[b]furans will probably be paid attention.

Keywords: Benzo[b]furan, cyclization, 2-ynylphenols, synthesis, one-pot, sequence

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(E-pub Ahead of Print)
DOI: 10.2174/1570179417666200625212639
Price: $95

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