Thiamine hydrochloride is reported to be highly competent promoter for the synthesis of bis(indolyl)methanes
under solvent free conditions using microwave irradiation and ultrasonicator heating in aqueous media. Vitamin B1 is an
economical, non-toxic, nonflammable and water soluble green organocatalyst. Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of thiamine hydrochloride makes this method an alternative
approach. Present protocol is a simple and eco-friendly approach for the synthesis of bis(indolyl)methanes under microwave
and ultrasonicator condition.
Keywords: Microwave condition, ultrasonicator condition, green catalyst, vitamin B1, one-pot synthesis, solvent free
Rights & PermissionsPrintExport