Efficient and Green Synthesis of Bis(indolyl)Methanes using Thiamine Hydrochloride as an Organocatalyst: A Parallel Scrutiny of Microwave Irradiation versus Ultrasonicator Heating in Water

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Author(s): Nitin M. Thorat*, Kiran D. Dhawale, Sandeep B. Kasar, Manali S. Thopate, Limbraj R. Patil, Shankar R. Thopate

Journal Name: Current Organic Synthesis

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Thiamine hydrochloride is reported to be highly competent promoter for the synthesis of bis(indolyl)methanes under solvent free conditions using microwave irradiation and ultrasonicator heating in aqueous media. Vitamin B1 is an economical, non-toxic, nonflammable and water soluble green organocatalyst. Moreover, the simple approach, easily operational, short reaction time, high yield and using a little quantity of thiamine hydrochloride makes this method an alternative approach. Present protocol is a simple and eco-friendly approach for the synthesis of bis(indolyl)methanes under microwave and ultrasonicator condition.

Keywords: Microwave condition, ultrasonicator condition, green catalyst, vitamin B1, one-pot synthesis, solvent free condition.

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(E-pub Ahead of Print)
DOI: 10.2174/1570179417666200620215101
Price: $95

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